Evidence map›Paper›PMID 33771858›Full record

ArticleScience advances2021

IFNAR1 signaling in NK cells promotes persistent virus infection.

Zhe Huang, Seung Goo Kang, Yunqiao Li, Jaroslav Zak, Namir Shaabani, Kaiyuan Deng, Jovan Shepherd, Raag Bhargava, John R Teijaro, Changchun Xiao

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  10. B cell-derived IL-27 promotes control of persistent LCMV infection.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 4 countries.

Zhe HuangDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-1312-5457
Seung Goo KangDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0003-3981-1399
Yunqiao LiDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Jaroslav ZakDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-8135-856X
Namir ShaabaniDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0003-3548-5899
Kaiyuan DengDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Jovan ShepherdDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0003-2067-550X
Raag BhargavaDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
John R TeijaroDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA. cxiao@scripps.edu teijaro@scripps.edu.ORCID 0000-0001-8280-8887
Changchun XiaoDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA. cxiao@scripps.edu teijaro@scripps.edu.ORCID 0000-0001-8754-3208
Scripps Research Institute · US

Funding

Functional Analysis of MicroRNAs and Target Genes in Immune ToleranceR01AI137252 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI NEMAZEE, DAVID · 2019 to 2024
$2.9M
Regulation of T Follicular Helper Cell Differentiation by MicroRNAsR01AI121155 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI NEMAZEE, DAVID · 2016 to 2020
$2.8M
IL-27 elicited antibodies: A novel means to control persistent Arenavirus infectionR01AI118862 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI TEIJARO, JOHN ROSS · 2016 to 2020
$2.4M
Novel Strategies for Controlling Persistent Viral InfectionR01AI123210 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI TEIJARO, JOHN ROSS · 2016 to 2019
$1.9M
Novel Regulators of B Cell ToleranceR21AI143529 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI NEMAZEE, DAVID · 2019 to 2020
$532k
Regulation of T Follicular Helper Cell Differentiation by MicroRNAsR56AI121155 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI XIAO, CHANGCHUN · 2016 to 2016
$131k
NIAID NIH HHS R01 AI118862NIAID NIH HHS R01 AI121155NIAID NIH HHS R01 AI123210NIAID NIH HHS R01 AI137252NIAID NIH HHS R21 AI143529NIAID NIH HHS R56 AI121155
6 · The paper itself

Abstract

Inhibition of type 1 interferon (IFN-I) signaling promotes the control of persistent virus infection, but the underlying mechanisms remain poorly understood. Here, we report that genetic ablation of

Indexed as

Interferon Type IVirus DiseasesAnimalsAntiviral AgentsCD8-Positive T-LymphocytesHumansKiller Cells, NaturalMiceMice, Inbred C57BLReceptor, Interferon alpha-betaAntiviral AgentsIFNAR1 protein, humanIfnar1 protein, mouseInterferon Type IReceptor, Interferon alpha-beta

Identifiers

PMID33771858
PMCPMC7997497
OpenAlexW3138161446

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.