Evidence map›Paper›PMID 33771533›Full record

ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2021

An Examination of the Association Between Subjective Distress and Functional Connectivity During Discarding Decisions in Hoarding Disorder.

Hannah C Levy, Andrew Poppe, Jaryd Hiser, Bethany M Wootton, Lauren S Hallion, David F Tolin, Michael C Stevens

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Hannah C LevyAnxiety Disorders Center, Institute of Living, Hartford, Connecticut. Electronic address: hannah.levy@hhchealth.org.
Andrew PoppeOlin Neuropsychiatry Research Center, Institute of Living, Hartford, Connecticut.
Jaryd HiserAnxiety Disorders Center, Institute of Living, Hartford, Connecticut.
Bethany M WoottonAnxiety Disorders Center, Institute of Living, Hartford, Connecticut; Discipline of Clinical Psychology, Graduate School of Health, University of Technology Sydney, Sydney, South Wales, Australia.
Lauren S HallionAnxiety Disorders Center, Institute of Living, Hartford, Connecticut; Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania.
David F TolinAnxiety Disorders Center, Institute of Living, Hartford, Connecticut; Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut.
Michael C StevensOlin Neuropsychiatry Research Center, Institute of Living, Hartford, Connecticut; Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut.
Institute for Community Living · USYale University · USUniversity of Pittsburgh · USUniversity of Technology Sydney · AU

Funding

Neural Mechanisms of CBT Response in Hoarding DisorderR01MH101163 · NIMH · HARTFORD HOSPITAL · PI STEVENS, MICHAEL C, TOLIN, DAVID F · 2013 to 2017
$2.8M
NIMH NIH HHS R01 MH101163
6 · The paper itself

Abstract

backgroundIndividuals with hoarding disorder (HD) demonstrate exaggerated subjective distress and hyperactivation of cingulate and insular cortex regions when discarding personal possessions. No prior study has sought to determine whether this subjective distress is associated with specific profiles of abnormal brain function in individuals with HD.

methodsWe used multimodal canonical correlation analysis plus joint independent component analysis to test whether five hoarding-relevant domains of subjective distress when deciding to discard possessions (anxiety, sadness, monetary value, importance, and sentimental attachment) are associated with functional magnetic resonance imaging-measured whole-brain functional connectivity in 72 participants with HD and 44 healthy controls.

resultsThree extracted components differed between HD participants and healthy control subjects. Each of these components depicted an abnormal profile of functional connectivity in HD participants relative to control subjects during discarding decisions, and a specific distress response profile. One component pair showed a relationship between anxiety ratings during discarding decisions and connectivity among the pallidum, perirhinal ectorhinal cortex, and dorsolateral prefrontal cortex. Another component comprised sadness ratings during discarding decisions and connectivity in the pallidum, nucleus accumbens, amygdala, and dorsolateral prefrontal cortex. The third component linked HD brain connectivity in several dorsolateral prefrontal cortex regions with perceived importance ratings during discarding decisions.

conclusionsThe findings indicate that in patients with HD, the subjective intensity of anxiety, sadness, and perceived possession importance is related to abnormal functional connectivity in key frontal and emotional processing brain regions. The findings are discussed in terms of emerging neurobiological models of HD.

Indexed as

Hoarding DisorderAnxietyAnxiety DisordersEmotionsHumansMagnetic Resonance ImagingCanonical correlation analysisDiscardingfMRIFunctional connectivityHoarding disorderIndependent component analysis

Identifiers

PMID33771533
PMCPMC8273210
OpenAlexW3118699226

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.