ArticleThe Journal of investigative dermatology2021
Prurigo Nodularis Is Characterized by Systemic and Cutaneous T Helper 22 Immune Polarization.
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Article in The Journal of investigative dermatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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49citing papers in PubMed
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Who cites it
49 citing papers in PubMed, 90 citations in OpenAlex.
- Dupilumab in patients with prurigo nodularis: two randomized, double-blind, placebo-controlled phase 3 trials.Nature medicine · 2023Trial
- Immunopathogenesis of itch: an integrative framework for chronic pruritus.JID innovations : skin science from molecules to population health · 2026Review
- Diagnostic Usefulness of Immunohistochemical Staining for EMA in Psoriasis and Atopic Dermatitis Showing Psoriasiform Hyperplasia.Annals of dermatology · 2026Article
- The State of the Art in Chronic Prurigo Nodularis.Dermatology and therapy · 2026Review
- Comprehensive Transcriptomic Profiling of Nonatopic Prurigo Nodularis in Korean Patients Reveals Il-22-driven Epidermal Stress and Neuro-immuno-fibrotic Remodelling.Acta dermato-venereologica · 2026Article
- Article
- Nanostring Transcriptomic Analysis Highlights IL-6 Family and TGF-β Pathways in the Pathogenesis of Prurigo Nodularis.JID innovations : skin science from molecules to population health · 2026Article
- Prurigo Nodularis and the Pain Cascade: Understanding the Pathogenesis and Approach to Management.The Journal of clinical and aesthetic dermatology · 2026Review
- New-onset Autoimmune Diseases in Patients with Prurigo Nodularis: A Global-federated Retrospective Cohort Study.Acta dermato-venereologica · 2025Article
- Serum SERPINB3/4 in Moderate-to-Severe Prurigo Nodularis: A Potential Biomarker for Disease Severity and Eosinophil-Related Parameters.Immunity, inflammation and disease · 2025Article
- An unbiased tissue transcriptome analysis identifies potential markers for skin phenotypes and therapeutic responses in atopic dermatitis.Nature communications · 2025Article
- Phenotype-endotype relationship in elderly atopic dermatitis and effects of dupilumab therapy: prospective study.Archives of dermatological research · 2025Article
- Targeted dual biologic therapy for erythroderma of unknown etiology guided by high-parameter peripheral blood immunophenotyping.Scientific reports · 2025Article
- Transcriptomic analysis of skin biopsies in Prurigo nodularis patients: with and without atopic dermatitis.Frontiers in immunology · 2025Article
- A murine model of prurigo nodularis-like skin lesions induced by persistent scratching under type 2 inflammatory conditions.Frontiers in immunology · 2025Article
- Spatial Mass Cytometry-Based Single-Cell Imaging Reveals a Disrupted Epithelial-Immune Axis in Prurigo Nodularis.The Journal of investigative dermatology · 2024Article
- Th Pathways in Immune-Mediated Skin Disorders: A Guide for Strategic Treatment Decisions.Immune network · 2024Review
- Dupilumab Therapy Modulates Circulating Inflammatory Mediators in Patients with Prurigo Nodularis.JID innovations : skin science from molecules to population health · 2024Article
- Prurigo nodularis: new insights into pathogenesis and novel therapeutics.The British journal of dermatology · 2024Review
- Prurigo Nodularis: Pathogenesis and the Horizon of Potential Therapeutics.International journal of molecular sciences · 2024Review
Corrections and comments
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Authors and funding
29 authors at 4 institutions in 1 country.
Micah BelzbergDepartment of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Martin Prince AlphonseDepartment of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Isabelle BrownDepartment of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Kyle A WilliamsDepartment of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Raveena KhannaDepartment of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Byron HoDepartment of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Shannon WongvibulsinDepartment of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Thomas PritchardDepartment of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Youkyung Sophie RohDepartment of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Nishadh SutariaDepartment of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Justin ChoiDepartment of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Jaroslaw JedrychDepartment of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Andrew D JohnstonCenter for Epigenomics and Department of Genetics (Division of Genomics), Albert Einstein College of Medicine, New York, New York, USA.
Kakali SarkarGenetic Resources Core Facility, McKusick- Nathans Department of Genetic Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Chirag VasavdaDepartment of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Jimmy MeixiongDepartment of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Carly DillenDepartment of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Kent BondesgaardKiniksa Pharmaceuticals, Corp., Lexington, Massachusetts, USA.
John F PaoliniKiniksa Pharmaceuticals, Corp., Lexington, Massachusetts, USA.
Wei ChenDuke Center for Genomic and Computational Biology, Duke Medicine, Duke University, Durham, North Carolina, USA.
David CorcoranDuke Center for Genomic and Computational Biology, Duke Medicine, Duke University, Durham, North Carolina, USA.
Nicolas DevosDuke Center for Genomic and Computational Biology, Duke Medicine, Duke University, Durham, North Carolina, USA.
Madan M KwatraDuke Anesthesiology, Duke University School of Medicine, Durham, North Carolina, USA.
Anna L ChienDepartment of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Nathan K ArcherDepartment of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Luis A GarzaDepartment of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Xinzhong DongDepartment of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA; The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Sewon KangDepartment of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Shawn G KwatraDepartment of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA. Electronic address: skwatra1@jhmi.edu.
Johns Hopkins University · USDuke University · USSynta Pharmaceuticals (United States) · USAlbert Einstein College of Medicine · US
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007309 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI COX, ANDREA L · 1985 to 2019
$43.2MMedical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4MRetinoic acid synthesis induced by noncoding dsRNA controls RegenerationR01AR074846 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI GARZA, LUIS ANDRES · 2019 to 2023
$2.3MIL-36 responses in Staphylococcus aureus driven skin inflammationR01AR073665 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI ARCHER, NATHAN K. · 2018 to 2022
$1.8MSTAT3-mediated immunity to Staphylococcus aureus in skinR01AR069502 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI ARCHER, NATHAN K. · 2016 to 2020
$1.8MSudden Cardiac Arrest (SCA): Prediction and PreventionF30HL142131 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI WONGVIBULSIN, SHANNON · 2018 to 2020
$135kNHLBI NIH HHS F30 HL142131NIAMS NIH HHS R01 AR069502NIAMS NIH HHS R01 AR073665NIAMS NIH HHS R01 AR074846NIGMS NIH HHS T32 GM007309NIGMS NIH HHS T32 GM136577
Abstract
Prurigo nodularis (PN) is an understudied, chronic inflammatory skin disease that disproportionately affects African Americans and presents with intensely pruritic nodules of unknown etiology. To better characterize the immune dysregulation in PN, PBMCs and skin biopsies were obtained from patients with PN and healthy subjects (majority African American) matched by age, race, and sex. Flow cytometric analysis of functional T-cell response comparing patients with PN with healthy subjects identified increased γδT cells (CD3
Indexed as
AdultAgedCell DifferentiationCells, CulturedFemaleHumansImmunity, CellularInterleukin-22InterleukinsLymphocyte ActivationMaleMiddle AgedPrurigoReceptors, InterleukinSequence Analysis, RNASkinIL22RA2 protein, humanInterleukin-22interleukin-22 receptorInterleukinsReceptors, Interleukin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.