Evidence map›Paper›PMID 33771189›Full record

ArticleArthritis research & therapy2021

Impact of disease activity on impaired glucose metabolism in patients with rheumatoid arthritis.

Gorica G Ristić, Vesna Subota, Dejana Stanisavljević, Danilo Vojvodić, Arsen D Ristić, Branislava Glišić, Milan Petronijević, Dušan Z Stefanović

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis research & therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Metabolic Consequences of Rheumatoid Arthritis.Arthritis care & research · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Gorica G RistićDepartment of Rheumatology and Clinical Immunology of the Military Medical Academy and Medical Faculty of the Military Medical Academy, University of Defense in Belgrade, Crnotravska 17, Belgrade, 11000, Serbia. goricaris@eunet.rs.ORCID 0000-0001-5760-492X
Vesna SubotaInstitute of Medical Biochemistry of the Military Medical Academy and Medical Faculty of the Military Medical Academy, University of Defense in Belgrade, Belgrade, Serbia.
Dejana StanisavljevićInstitute of Medical Statistics, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Danilo VojvodićInstitute for Medical Research of the Military Medical Academy and Medical Faculty of the Military Medical Academy, University of Defense in Belgrade, Belgrade, Serbia.
Arsen D RistićDepartment of Cardiology of the University Clinical Centre of Serbia and Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Branislava GlišićDepartment of Rheumatology and Clinical Immunology of the Military Medical Academy and Medical Faculty of the Military Medical Academy, University of Defense in Belgrade, Crnotravska 17, Belgrade, 11000, Serbia.
Milan PetronijevićDepartment of Rheumatology and Clinical Immunology of the Military Medical Academy and Medical Faculty of the Military Medical Academy, University of Defense in Belgrade, Crnotravska 17, Belgrade, 11000, Serbia.
Dušan Z StefanovićDepartment of Rheumatology and Clinical Immunology of the Military Medical Academy and Medical Faculty of the Military Medical Academy, University of Defense in Belgrade, Crnotravska 17, Belgrade, 11000, Serbia.
Military Medical Academy · RSUniversity of Belgrade · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore glucose metabolism in rheumatoid arthritis (RA) and its association with insulin resistance (IR) risk factors and disease activity indicators, including matrix metalloproteinase-3 (MMP3).

methodsThis single-center study included 127 non-diabetic subjects: 90 RA patients and 37 matched controls. IR-related risk factors, disease activity (DAS28-ESR/CRP), concentrations of inflammation markers, MMP3, glucose, specific insulin, and C-peptide (a marker of β-cell secretion) were determined. Homeostasis Model Assessment was used to establish insulin resistance (HOMA2-IR) and sensitivity (HOMA2-%S). Associations of HOMA2 indices with IR-related risk factors, inflammation markers, and RA activity were tested using multiple regression analyses.

resultsRA patients had significantly increased HOMA2-IR index than controls. In the RA group, multivariate analysis revealed DAS28-ESR, DAS28-CRP, tender joint counts, patient's global assessment, and MMP3 level as significant positive predictors for HOMA2-IR (β = 0.206, P = 0.014; β = 0.192, P = 0.009; β = 0.121, P = 0.005; β = 0.148, P = 0.007; β = 0.075, P = 0.025, respectively), and reciprocal negative for HOMA2-%S index. According to the value of the coefficient of determination (R

conclusionsRA activity is an independent risk factor for impaired glucose metabolism. DAS28-ESR ≥ 5.1 was the main contributor to this metabolic disturbance, followed by MMP3 concentration, outweighing the impact of classic IR-related risk factors.

Indexed as

Arthritis, RheumatoidInsulin ResistanceBiomarkersBlood SedimentationC-Reactive ProteinGlucoseHumansRisk FactorsSeverity of Illness IndexBiomarkersC-Reactive ProteinGlucoseInsulin resistanceMatrix metalloproteinase-3Rheumatoid arthritis

Identifiers

PMID33771189
PMCPMC7995801
OpenAlexW3136302007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.