ArticleJournal of orthopaedic surgery and research2021
The effect of denosumab on pedicle screw fixation: a prospective 2-year longitudinal study using finite element analysis.
Article in Journal of orthopaedic surgery and research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Osteoporosis and adult spinal deformity-a review for spinal surgeons by the SRS adult spinal deformity task force on senescence.Spine deformity · 2026Review
- Osteoporosis and osteoporosis therapies as determinants of implant fixation failure in arthroplasty and spinal fusion constructs: a position statement from the Fracture Working Group of the Council of Scientific Advisors of the International Osteoporosis Foundation.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Review
- Verification of ideal screw size, trajectory, and shape for single and double endplate penetrating screw trajectories using osteoporotic vertebral body models based on the finite element method.Asian spine journal · 2026Article
- Bone Optimization for Perioperative Spine Patients: A Multidisciplinary Approach at a Single Academic Center.Journal of clinical medicine · 2025Article
- Comparative Finite Element Analysis of Denosumab and Bazedoxifene on Pedicle Screw Stability in Osteoporotic Spines.JOR spine · 2025Article
- The Role of Osteoporosis in Spine Surgery and Current Management Strategies: A Review.Current osteoporosis reports · 2025Review
- Optimizing bone health for the prevention of revision adult spinal deformity surgery: a break-even analysis.Spine deformity · 2025Article
- A comprehensive review of risk factors and prevention strategies: how to minimize mechanical complications in corrective surgery for adult spinal deformity.Asian spine journal · 2025Article
- Impact of Frailty and Other Factors as Estimated by HU to Predict Response to Anabolic Bone Medications.Journal of clinical medicine · 2025Article
- The ratio between the screw distance and femoral neck width on lateral radiography is a reliable predictor of femoral head necrosis: a clinical review and corresponding numerical simulations.Journal of orthopaedic surgery and research · 2024Article
- Surgical Management of Adult Spinal Deformity Patients with Osteoporosis.Journal of clinical medicine · 2024Review
- Low bone mineral density: a primer for the spine surgeon.Spine deformity · 2024Review
- The potential effect of romosozumab on perioperative management for instrumentation surgery.JOR spine · 2024Article
- Spinal alignment and surgical correction in the aging spine and osteoporotic patient.North American Spine Society journal · 2024Review
- Bone Health Optimization in Adult Spinal Deformity Patients: A Narrative Review.Journal of clinical medicine · 2024Review
- Impact of screw tip design on screw anchorage: mechanical testing and numerical simulation.Journal of orthopaedic surgery and research · 2024Article
- Comparison of the Fixation Strengths of Screws between the Traditional Trajectory and the Single and Double Endplate Penetrating Screw Trajectories Using Osteoporotic Vertebral Body Models Based on the Finite Element Method.Asian spine journal · 2024Article
- Effects of anti-osteoporosis treatment in elderly patients with osteoporosis and lumbar discectomy and fusion.Journal of back and musculoskeletal rehabilitation · 2024Article
- Efficacy and safety of different anti-osteoporotic drugs for the spinal fusion surgery: A network meta-analysis.World journal of clinical cases · 2023Article
- [Efficacy analysis of autologous facet joint bone block in lumbar interbody fusion of osteoporosis patients].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
backgroundPedicle screw loosening is a major complication following spinal fixation associated with osteoporosis in elderly. However, denosumab is a promising treatment in patients with osteoporosis. The effect of denosumab on pedicle screw fixation is unknown. Therefore, we investigated whether denosumab treatment improves pedicle screw fixation in elderly patients with osteoporosis.
methodsThis was a 2-year prospective open-label study. From February 2015 to January 2016, we included 21 patients with postmenopausal osteoporosis who received initial denosumab treatment. At baseline, 12 months, and 24 months, we measured volumetric bone mineral density (BMD) using quantitative computed tomography (QCT) and performed CT-based finite element analysis (FEA). Finite element models of L4 vertebrae were created to analyze the bone strength and screw fixation.
resultsBMD increased with denosumab treatment. FEA revealed that both pullout strength of pedicle screws and compression force of the vertebra increased significantly at 12 and 24 months following denosumab treatment. Notably, pullout strength showed a stronger correlation with three-dimensional volumetric BMD around pedicle screw placement assessed by QCT (r = 0.83, at 24 months) than with two-dimensional areal BMD assessed by dual energy X-ray absorptiometry (r = 0.35, at 24 months).
conclusionTo our knowledge, this is the first study to reveal that denosumab treatment achieved strong pedicle screw fixation with an increase in BMD around the screw assessed by QCT and FEA; therefore, denosumab could be useful for osteoporosis treatment during spinal surgery in elderly patients with osteoporosis.
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