ReviewMicrobial cell factories2021
Microbial production of ectoine and hydroxyectoine as high-value chemicals.
Review in Microbial cell factories, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
56 citing papers in PubMed, 131 citations in OpenAlex.
- Data-driven optimization of salt shock for high-efficiency ectoine production inSynthetic and systems biotechnology · 2027Article
- Genomic and physiological characterization of newly isolated nitrous oxide-reducing bacteriumApplied and environmental microbiology · 2026Article
- Taxogenomic and Physiological Characterization ofInternational journal of molecular sciences · 2026Article
- Metagenomic insights into the taxonomic and metabolic diversity of the microbiome of Lake Karum in the Danakil Depression, Ethiopia.Environmental microbiome · 2026Article
- Deep subsurface rock-hosted chemolithotrophic bacterial communities exhibited differential COScientific reports · 2026Article
- Biotechnological Potential of Quorum Quenching Bacterial Strains Isolated fromAnimals : an open access journal from MDPI · 2026Article
- Article
- Genotypic characterization of gut isolates from Atlantic salmon fry reveals beneficial microbes with biotechnological potential.Applied and environmental microbiology · 2026Article
- Genomic, biological, and chemical studies of Streptomyces sp. LaBMicrA B280 isolated from the rhizosphere of Inga edulis Martius in the Amazon.Antonie van Leeuwenhoek · 2026Article
- Harnessing Biogas into High-Value Chemicals: The Role of Algal-Methanotrophic Co-Cultures.Marine drugs · 2026Article
- Reducing the sensitivity of Halomonas sp. to oxygen availability through adaptive laboratory evolution.Microbial cell factories · 2026Article
- Characterization of Streptomyces tatrensis sp. nov., isolated from a cave located in Tatra mountains in Poland.Archives of microbiology · 2026Article
- Ectoine as a multifunctional molecule: biotechnological production and pharmaceutical applications.Drug delivery and translational research · 2026Review
- Identification and Cultivation of Biotechnologically Relevant Microalgal and Cyanobacterial Species Isolated from Sečovlje Salt Pans, Slovenia.Marine drugs · 2026Article
- Metabolic response ofFrontiers in microbiology · 2026Article
- Exploring Ectoine Production From Methanol, Formate, and Electrochemically Produced Formate byEngineering in life sciences · 2026Article
- Decoding metabolic trade-offs inSynthetic and systems biotechnology · 2025Article
- Extremophile-Derived Bioactives in Cosmeceuticals: Bridging Nutraceuticals and Skincare for Holistic Wellness.Life (Basel, Switzerland) · 2025Review
- Identification of poultry commensal bacteria with the ability to inhibit the growth of Salmonella enterica serovar Typhimurium in co-culture.BMC microbiology · 2025Article
- Mechanistic insights into the delayed yellowing of broccoli by the combination of ectoine and lactide peptide.NPJ science of food · 2025Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Ectoine and hydroxyectoine as typical representatives of compatible solutes are not only essential for extremophiles to survive in extreme environments, but also widely used in cosmetic and medical industries. Ectoine was traditionally produced by Halomonas elongata through a "bacterial milking" process, of which the marked feature is using a high-salt medium to stimulate ectoine biosynthesis and then excreting ectoine into a low-salt medium by osmotic shock. The optimal hydroxyectoine production was achieved by optimizing the fermentation process of Halomonas salina. However, high-salinity broth exacerbates the corrosion to fermenters, and more importantly, brings a big challenge to the subsequent wastewater treatment. Therefore, increasing attention has been paid to reducing the salinity of the fermentation broth but without a sacrifice of ectoine/hydroxyectoine production. With the fast development of functional genomics and synthetic biology, quite a lot of progress on the bioproduction of ectoine/hydroxyectoine has been achieved in recent years. The importation and expression of an ectoine producing pathway in a non-halophilic chassis has so far achieved the highest titer of ectoine (~ 65 g/L), while rational flux-tuning of halophilic chassis represents a promising strategy for the next-generation of ectoine industrial production. However, efficient conversion of ectoine to hydroxyectoine, which could benefit from a clearer understanding of the ectoine hydroxylase, is still a challenge to date.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.