Evidence map›Paper›PMID 33771147›Full record

ArticleBMC oral health2021

Pathophysiological mechanisms of root resorption after dental trauma: a systematic scoping review.

Kerstin M Galler, Eva-Maria Grätz, Matthias Widbiller, Wolfgang Buchalla, Helge Knüttel

Open access · goldAbstract readScoping Review
In one paragraph

Article in BMC oral health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Prevalence of Post-Operative Complications in Autotransplanted Teeth: A Long-Term Retrospective Cohort.Dental traumatology : official publication of International Association for Dental Traumatology · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Observational
  11. Article
  12. Survival and Success of Teeth Involved in Alveolar Bone Injuries: Up to 10 Years of Follow-Up.Dental traumatology : official publication of International Association for Dental Traumatology · 2026
    Article
  13. The effects of splinting wire material and dimension on ankylosis and root resorption in luxated incisors: a rodent histological study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026
    Article
  14. [Research progress on external cervical resorption].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. [Heterotopic replantation and delayed implant restoration following complete avulsion of maxillary central incisors: a case report].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Kerstin M GallerDepartment of Conservative Dentistry and Periodontology, University Hospital Regensburg, Franz-Josef-Strauß Allee 11, 93053, Regensburg, Germany. kerstin.galler@klinik.uni-regensburg.de.
Eva-Maria GrätzDepartment of Conservative Dentistry and Periodontology, University Hospital Regensburg, Franz-Josef-Strauß Allee 11, 93053, Regensburg, Germany.
Matthias WidbillerDepartment of Conservative Dentistry and Periodontology, University Hospital Regensburg, Franz-Josef-Strauß Allee 11, 93053, Regensburg, Germany.ORCID 0000-0002-7917-9466
Wolfgang BuchallaDepartment of Conservative Dentistry and Periodontology, University Hospital Regensburg, Franz-Josef-Strauß Allee 11, 93053, Regensburg, Germany.
Helge KnüttelUniversity Library, University of Regensburg, Regensburg, Germany.ORCID 0000-0002-2654-6517
University Hospital Regensburg · DEUniversity of Regensburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe objective of this scoping review was to systematically explore the current knowledge of cellular and molecular processes that drive and control trauma-associated root resorption, to identify research gaps and to provide a basis for improved prevention and therapy.

methodsFour major bibliographic databases were searched according to the research question up to February 2021 and supplemented manually. Reports on physiologic, histologic, anatomic and clinical aspects of root resorption following dental trauma were included. Duplicates were removed, the collected material was screened by title/abstract and assessed for eligibility based on the full text. Relevant aspects were extracted, organized and summarized.

results846 papers were identified as relevant for a qualitative summary. Consideration of pathophysiological mechanisms concerning trauma-related root resorption in the literature is sparse. Whereas some forms of resorption have been explored thoroughly, the etiology of others, particularly invasive cervical resorption, is still under debate, resulting in inadequate diagnostics and heterogeneous clinical recommendations. Effective therapies for progressive replacement resorptions have not been established. Whereas the discovery of the RANKL/RANK/OPG system is essential to our understanding of resorptive processes, many questions regarding the functional regulation of osteo-/odontoclasts remain unanswered.

conclusionsThis scoping review provides an overview of existing evidence, but also identifies knowledge gaps that need to be addressed by continued laboratory and clinical research.

Indexed as

Root ResorptionHumansOsteoclastsOsteoprotegerinOsteoprotegerinOsteoclastOsteoprotegerinRANK ligandReceptor activator of nuclear factor-kappa BRoot resorptionTooth resorption

Identifiers

PMID33771147
PMCPMC7995728
OpenAlexW3139303293

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.