Evidence map›Paper›PMID 33771127›Full record

ArticleBMC gastroenterology2021

The incidence and prevalence of inflammatory bowel disease in UK primary care: a retrospective cohort study of the IQVIA Medical Research Database.

Karoline Freeman, Ronan Ryan, Nicholas Parsons, Sian Taylor-Phillips, Brian H Willis, Aileen Clarke

Abstract read
In one paragraph

Article in BMC gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Karoline FreemanWarwick Medical School, University of Warwick, Coventry, UK. k.freeman@warwick.ac.uk.ORCID http://orcid.org/0000-0002-9963-2918
Ronan RyanInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.
Nicholas ParsonsWarwick Medical School, University of Warwick, Coventry, UK.
Sian Taylor-PhillipsWarwick Medical School, University of Warwick, Coventry, UK.
Brian H WillisInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.
Aileen ClarkeWarwick Medical School, University of Warwick, Coventry, UK.

Funding

Medical Research Council MR/N007999/1Research Trainees Coordinating Centre DRF-2016-09-038
6 · The paper itself

Abstract

backgroundOur knowledge of the incidence and prevalence of inflammatory bowel disease (IBD) is uncertain. Recent studies reported an increase in prevalence. However, they excluded a high proportion of ambiguous cases from general practice. Estimates are needed to inform health care providers who plan the provision of services for IBD patients. We aimed to estimate the IBD incidence and prevalence in UK general practice.

methodsWe undertook a retrospective cohort study of routine electronic health records from the IQVIA Medical Research Database covering 14 million patients. Adult patients from 2006 to 2016 were included. IBD was defined as an IBD related Read code or record of IBD specific medication. Annual incidence and 12-month period prevalence were calculated.

resultsThe prevalence of IBD increased between 2006 and 2016 from 106.2 (95% CI 105.2-107.3) to 142.1 (95% CI 140.7-143.5) IBD cases per 10,000 patients which is a 33.8% increase. Incidence varied across the years. The incidence across the full study period was 69.5 (95% CI 68.6-70.4) per 100,000 person years.

conclusionsIn this large study we found higher estimates of IBD incidence and prevalence than previously reported. Estimates are highly dependent on definitions of disease and previously may have been underestimated.

Indexed as

Biomedical ResearchInflammatory Bowel DiseasesAdultHumansIncidencePrevalencePrimary Health CareRetrospective StudiesUnited KingdomElectronic health care recordsEpidemiologyInflammatory bowel diseasePrimary health care

Identifiers

PMID33771127
PMCPMC8004426

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.