Evidence map›Paper›PMID 33770547›Full record

ArticleNeuroImage. Clinical2021

Brainstem functional oscillations across the migraine cycle: A longitudinal investigation.

Noemi Meylakh, Kasia K Marciszewski, Flavia Di Pietro, Vaughan G Macefield, Paul M Macey, Luke A Henderson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Noemi MeylakhDepartment of Anatomy and Histology, University of Sydney, Sydney, NSW 2006, Australia. Electronic address: noemi.meylakh@sydney.edu.au.
Kasia K MarciszewskiDepartment of Anatomy and Histology, University of Sydney, Sydney, NSW 2006, Australia.
Flavia Di PietroSchool of Pharmacy and Biomedical Sciences, Curtin University, Perth, Australia.
Vaughan G MacefieldSchool of Medicine, Western Sydney University, Sydney, Australia.
Paul M MaceyUCLA School of Nursing and Brain Research Institute, University of California, Los Angeles, CA 90095, United States.
Luke A HendersonDepartment of Anatomy and Histology, University of Sydney, Sydney, NSW 2006, Australia.
The University of Sydney · AUCurtin University · AUUniversity of California, Los Angeles · USWestern Sydney University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although the mechanisms responsible for migraine initiation remain unknown, recent evidence shows that brain function is different immediately preceding a migraine. This is consistent with the idea that altered brain function, particularly in brainstem sites, may either trigger a migraine or facilitate a peripheral trigger that activates the brain, resulting in pain. The aim of this longitudinal study is therefore to expand on the above findings, and to determine if brainstem function oscillates over a migraine cycle in individual subjects. We performed resting state functional magnetic resonance imaging in three migraineurs and five controls each weekday for four weeks. We found that although resting activity variability was similar in controls and interictal migraineurs, brainstem variability increased dramatically during the 24-hour period preceding a migraine. This increase occurred in brainstem areas in which orofacial afferents terminate: the spinal trigeminal nucleus and dorsal pons. These increases were characterized by increased power at infra-slow frequencies, principally between 0.03 and 0.06 Hz. Furthermore, these power increases were associated with increased regional homogeneity, a measure of local signal coherence. The results show within-individual alterations in brain activity immediately preceding migraine onset and support the hypothesis that altered regional brainstem function before a migraine attack is involved in underlying migraine neurobiology.

Indexed as

Migraine DisordersBrainBrain StemHumansLongitudinal StudiesMagnetic Resonance ImagingAstrocytesDorsal ponsInfra-slow oscillationsResting state functional magnetic resonance imagingSpinal trigeminal nucleus

Identifiers

PMID33770547
PMCPMC8024773
OpenAlexW3138647354

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.