ArticleNeurobiology of aging2021
GABA levels in ventral visual cortex decline with age and are associated with neural distinctiveness.
Article in Neurobiology of aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 59 citations in OpenAlex.
- Dynamic Recovery: GABA Agonism Restores Neural Variability in Older, Poorer Performing Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Trial
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- Decreased BOLD Signal Variability in Middle-Aged and Older Adults on the Autism Spectrum.Autism research : official journal of the International Society for Autism Research · 2026Article
- The puzzling duality of mesenchymal stem cells and adipocytes in bone marrow and ageing.npj aging · 2026Review
- Oral Supplementation With a Bovine Thymus Extract Reduces Neuronal Excitability in Aging Mice.FASEB bioAdvances · 2026Article
- AI-enabled multimodal neuroimaging for neurotransmitter mapping in normal aging and age-related disease.Frontiers in aging neuroscience · 2026Review
- The relationship between category-level neural differentiation and exploratory eye movements in healthy young and older adults.Neurobiology of aging · 2025Article
- Temporal dedifferentiation of neural states with age during naturalistic viewing.Communications biology · 2025Article
- GABA Levels Are Significantly Reduced in the Visual, Motor, and Auditory Cortex of Patients with Mild Cognitive Impairment.Aging and disease · 2025Article
- Modulation of brain signal variability in visual cortex reflects aging, GABA, and behavior.eLife · 2025Article
- "Surviving and Thriving": evidence for cortical GABA stabilization in cognitively-intact oldest-old adults.Translational psychiatry · 2025Article
- Age predicts peak gamma frequency and N1 amplitude of visual evoked potential.BMC neuroscience · 2025Article
- GABA, Glx, and GSH in the cerebellum: their role in motor performance and learning across age groups.Frontiers in aging neuroscience · 2025Article
- Dedifferentiation of caudate functional organization is linked to reduced D1 dopamine receptor availability and poorer memory function in aging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Behavioural stochastic resonance across the lifespan.Cognitive, affective & behavioral neuroscience · 2024Article
- Frontal GABA levels associate with musical rhythm production in healthy aging adults.Brain and cognition · 2024Article
- Age and visual cortex inhibition: a TMS-MRS study.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Age-Related Deficits in Binaural Hearing: Contribution of Peripheral and Central Effects.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Visual surround suppression at the neural and perceptual levels.Cognitive neurodynamics · 2024Review
- Dissociative Effects of Age on Neural Differentiation at the Category and Item Levels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
Age-related neural dedifferentiation-a decline in the distinctiveness of neural representations in the aging brain-has been associated with age-related declines in cognitive abilities. But why does neural distinctiveness decline with age? Based on prior work in nonhuman primates and more recent work in humans, we hypothesized that the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) declines with age and is associated with neural dedifferentiation in older adults. To test this hypothesis, we used magnetic resonance spectroscopy (MRS) to measure GABA and functional MRI (fMRI) to measure neural distinctiveness in the ventral visual cortex in a set of older and younger participants. Relative to younger adults, older adults exhibited lower GABA levels and less distinct activation patterns for faces and houses in the ventral visual cortex. Furthermore, individual differences in GABA within older adults positively predicted individual differences in neural distinctiveness. These results provide novel support for the view that age-related reductions of GABA contribute to age-related reductions in neural distinctiveness (i.e., neural dedifferentiation) in the human ventral visual cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.