ArticleNeuron2021
An activity-dependent determinant of synapse elimination in the mammalian brain.
Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 77 citations in OpenAlex.
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- Molecular and Cellular Mechanisms of Synaptogenesis and Synaptic Refinement During Cerebellar Circuit Formation.International journal of molecular sciences · 2026Review
- Metabolic expenditure, neurodevelopment, and weight gain into early childhood after fetal growth restriction.Scientific reports · 2026Article
- Viral modulation of synaptic pruning: implications for neuropathology and brain function.Journal of virology · 2026Review
- Microglia-Neuron Interactions in Alzheimer's Disease.Current neuropharmacology · 2026Review
- Microglial pathological synaptic pruning in epilepsy: pathophysiology and therapeutic potential.Frontiers in immunology · 2026Review
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- Synaptic pruning following NMDAR-dependent LTD preferentially affects isolated synapses.iScience · 2025Article
- Eye-specific differences in active zone addition during synaptic competition in the developing visual system.bioRxiv : the preprint server for biology · 2025Article
- Activity-driven proprioceptive synaptic refinement in the developing spinal cord by complement signaling mechanisms.bioRxiv : the preprint server for biology · 2025Article
- Experience-dependent control of synaptic remodeling and structural plasticity by glia.Current opinion in neurobiology · 2025Review
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- Electroacupuncture at ST25 mediated glial cells pruning of pancreatic TRPV1 neural synapse responds to neuropathy-associated beta cell dysfunction.Chinese medicine · 2025Article
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- Neural cell competition sculpting brain from cradle to grave.National science review · 2025Review
- Neuronal pSTAT1 hallmarks synaptic pathology in autoimmune encephalitis against intracellular antigens.Acta neuropathologica · 2025Article
- Prolonged STAT1 signaling in neurons causes hyperactive behavior.Brain, behavior, and immunity · 2025Article
- Activity-dependent synaptic competition and dendrite pruning in developing mitral cells.Frontiers in neural circuits · 2025Review
- Microglia as hunters or gatherers of brain synapses.Nature neuroscience · 2025Review
- Pharmacological evaluation of drug therapies in Aicardi-Goutières syndrome: insights from patient-derived neural stem cells.Frontiers in pharmacology · 2025Article
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4 authors at 1 institution in 1 country.
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Abstract
To establish functional neural circuits in the brain, synaptic connections are refined by neural activity during development, where active connections are maintained and inactive ones are eliminated. However, the molecular signals that regulate synapse refinement remain to be elucidated. When we inactivate a subset of neurons in the mouse cingulate cortex, their callosal connections are eliminated through activity-dependent competition. Using this system, we identify JAK2 tyrosine kinase as a key regulator of inactive synapse elimination. We show that JAK2 is necessary and sufficient for elimination of inactive connections; JAK2 is activated at inactive synapses in response to signals from other active synapses; STAT1, a substrate of JAK2, mediates inactive synapse elimination; JAK2 signaling is critical for physiological refinement of synapses during normal development; and JAK2 regulates synapse refinement in multiple brain regions. We propose that JAK2 is an activity-dependent switch that serves as a determinant of inactive synapse elimination.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.