ArticleAdvances in experimental medicine and biology2021
One-Carbon Metabolism and Development of the Conceptus During Pregnancy: Lessons from Studies with Sheep and Pigs.
Article in Advances in experimental medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Gestational Obesity Impairs Maternal Glucose Metabolism in Post-Partum Ewes.Animals : an open access journal from MDPI · 2025Article
- Conceptus Elongation, Implantation, and Early Placental Development in Species with Central Implantation: Pigs, Sheep, and Cows.Biomolecules · 2025Review
- Key biochemical pathways during pregnancy in livestock: mechanisms regulating uterine and placental development and function.Reproduction & fertility · 2025Review
- Roe deer uterine fluid metabolome reveals elevated glycolysis, fatty acid breakdown, and spermidine synthesis upon reactivation from diapause†.Biology of reproduction · 2025Article
- Image-guided metabolomics and transcriptomics reveal tumour heterogeneity in luminal A and B human breast cancer beyond glucose tracer uptake.Clinical and translational medicine · 2024Article
- Combined transcriptome and metabolome analysis reveals breed-specific regulatory mechanisms in Dorper and Tan sheep.BMC genomics · 2024Article
- Fructose metabolism is unregulated in cancers and placentae.Experimental biology and medicine (Maywood, N.J.) · 2024Review
- Synthesis of glycine from 4-hydroxyproline in tissues of neonatal pigs with intrauterine growth restriction.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Impact of probiotic Limosilactobacillus reuteri DSM 17938 on amino acid metabolism in the healthy newborn mouse.Amino acids · 2022Article
- Use of Agriculturally Important Animals as Models in Biomedical Research.Advances in experimental medicine and biology · 2022Review
- A Role for Fructose Metabolism in Development of Sheep and Pig Conceptuses.Advances in experimental medicine and biology · 2022Article
- Functional Molecules of Intestinal Mucosal Products and Peptones in Animal Nutrition and Health.Advances in experimental medicine and biology · 2022Article
- L-Arginine Nutrition and Metabolism in Ruminants.Advances in experimental medicine and biology · 2022Article
- Nutrition and Metabolism: Foundations for Animal Growth, Development, Reproduction, and Health.Advances in experimental medicine and biology · 2022Article
- Pigs (Sus Scrofa) in Biomedical Research.Advances in experimental medicine and biology · 2022Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pregnancy recognition signal from the conceptus (embryo/fetus and associated membranes) to the mother is interferon tau (IFNT) in ruminants and estradiol, possibly in concert with interferons gamma and delta in pigs. Those pregnancy recognition signals silence expression of interferon stimulated genes (ISG) in uterine luminal (LE) and superficial glandular (sGE) epithelia while inducing expression of genes for transport of nutrients, including glucose and amino acids, into the uterine lumen to support growth and development of the conceptus. In sheep and pigs, glucose not utilized immediately by the conceptus is converted to fructose. Glucose, fructose, serine and glycine in uterine histotroph can contribute to one carbon (1C) metabolism that provides one-carbon groups for the synthesis of purines and thymidylate, as well as S-adenosylmethionine for epigenetic methylation reactions. Serine and glycine are transported into the mitochondria of cells and metabolized to formate that is transported into the cytoplasm for the synthesis of purines, thymidine and S-adenosylmethionine. The unique aspects of one-carbon metabolism are discussed in the context of the hypoxic uterine environment, aerobic glycolysis, and similarities in metabolism between cancer cells and cells of the rapidly developing fetal-placental tissues during pregnancy. Further, the evolution of anatomical and functional aspects of the placentae of sheep and pigs versus primates is discussed in the context of mechanisms to efficiently obtain, store and utilize nutrients required for rapid fetal growth in the last one-half of gestation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.