Evidence map›Paper›PMID 33770382›Full record

ArticleEndocrine2021

Reduced fibroblast growth factor 21 and β-Klotho secretion in untreated congenital isolated GH deficiency.

Alécia A Oliveira-Santos, Roberto Salvatori, Ana C Bueno, Monica C Nogueira, Viviane C Campos, Manuela A Melo, Carla R P Oliveira, Cynthia S Barros-Oliveira, Cindi G Marinho, Nayra P Damascena and 5 more

Abstract read
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In one paragraph

Article in Endocrine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Alécia A Oliveira-SantosPostgraduate Nucleus in Health Science, Federal University of Sergipe, 49060-100, Aracaju, Brazil.
Roberto SalvatoriDivision of Endocrinology and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA. salvator@jhmi.edu.ORCID http://orcid.org/0000-0001-6495-2244
Ana C BuenoDepartment of Internal Medicine, The Ribeirao Preto Medical School, University of São Paulo, 14049-900, Ribeirao Preto, SP, Brazil.
Monica C NogueiraDepartment of Internal Medicine, The Ribeirao Preto Medical School, University of São Paulo, 14049-900, Ribeirao Preto, SP, Brazil.
Viviane C CamposPostgraduate Nucleus in Health Science, Federal University of Sergipe, 49060-100, Aracaju, Brazil.
Manuela A MeloPostgraduate Nucleus in Health Science, Federal University of Sergipe, 49060-100, Aracaju, Brazil.
Carla R P OliveiraPostgraduate Nucleus in Health Science, Federal University of Sergipe, 49060-100, Aracaju, Brazil.
Cynthia S Barros-OliveiraPostgraduate Nucleus in Health Science, Federal University of Sergipe, 49060-100, Aracaju, Brazil.
Cindi G MarinhoPostgraduate Nucleus in Health Science, Federal University of Sergipe, 49060-100, Aracaju, Brazil.
Nayra P DamascenaPostgraduate Nucleus in Health Science, Federal University of Sergipe, 49060-100, Aracaju, Brazil.
Elenilde G SantosPostgraduate Nucleus in Health Science, Federal University of Sergipe, 49060-100, Aracaju, Brazil.
Enaldo V MeloPostgraduate Nucleus in Health Science, Federal University of Sergipe, 49060-100, Aracaju, Brazil.
Francisco J A de PaulaDepartment of Internal Medicine, The Ribeirao Preto Medical School, University of São Paulo, 14049-900, Ribeirao Preto, SP, Brazil.
Margaret de CastroDepartment of Internal Medicine, The Ribeirao Preto Medical School, University of São Paulo, 14049-900, Ribeirao Preto, SP, Brazil.
Manuel H Aguiar-OliveiraPostgraduate Nucleus in Health Science, Federal University of Sergipe, 49060-100, Aracaju, Brazil.
Universidade Federal de Sergipe · BRUniversidade de São Paulo · BRJohns Hopkins University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposesIncreasing evidence suggests that the FGF-Klotho endocrine system and the somatotropic system (pituitary and extra-pituitary GH) may have important metabolic and immune relationships, thus contributing to the pathophysiology of aging-related disorders, including diabetes, atherosclerosis, and cancer. The status of these interactions in isolated GH deficiency (IGHD) is unknown. The objective of this study was to assess the response of both FGF21 and β-Klotho levels to a standard meal in a homogeneous group of adults with congenital untreated IGHD due to a homozygous mutation in the GHRH receptor gene.

methodsIn a cross-sectional study, we measured the levels of FGF21 and β-Klotho, before and 30, 60, 120, and 180 min after a standardized test meal in 20 (11 males) IGHD and 20 (11 males) age-matched controls. Areas under the curves (AUC) of FGF21 and β-Klotho were calculated.

resultsBaseline levels of FGF21 were similar, but baseline levels of β-Klotho were lower in IGHD subjects. The IGHD individuals exhibited lower AUC for FGF21 and β-Klotho levels than control subjects. There was a positive correlation between IGF1 and β-Klotho levels in the pooled groups. No correlation was found between IGF1 and FGF21 levels.

conclusionsSubjects with lifetime, untreated IGHD exhibit reduced FGF21 and β-Klotho levels response to a mixed meal. This difference may have consequences on metabolism and aging.

Indexed as

Dwarfism, PituitaryAdultAgingCross-Sectional StudiesFibroblast Growth FactorsHumansMaleFGF21 protein, humanfibroblast growth factor 21Fibroblast Growth FactorsFGF21GHMixed mealβ-Klotho

Identifiers

PMID33770382
OpenAlexW3137112594

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Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.