ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2021
Serum transthyretin and risk of cognitive decline and dementia: 22-year longitudinal study.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Unravelling the myriad physiologic roles of transthyretin: critical considerations for treating transthyretin amyloidosis.Annals of medicine · 2025Review
- Associations of maternal serum transthyretin concentration with pregnancy and birth outcomes.BMC pregnancy and childbirth · 2025Article
- Concurrent cardiac transthyretin and brain β amyloid accumulation among the older adults: The Hisayama study.Brain pathology (Zurich, Switzerland) · 2022Article
- Cognitive Status and Nutritional Markers in a Sample of Institutionalized Elderly People.Frontiers in aging neuroscience · 2022Article
- Association between transthyretin levels and Alzheimer's disease: A meta-analysis.Journal of Alzheimer's disease reportsArticle
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Serum transthyretin (TTR) may be an early biomarker for Alzheimer's disease and related disorders (ADRD). We investigated associations of TTR measured at baseline with cognitive decline and incident ADRD and whether TTR trajectories differ between ADRD cases and non-cases, over 22 years before diagnosis. A total of 6024 adults aged 45-69 in 1997-1999 were followed up until 2019. TTR was assessed three times, and 297 cases of dementia were recorded. Higher TTR was associated with higher cognitive function at baseline; however, TTR was unrelated to subsequent change in cognitive function. TTR at baseline did not predict ADRD risk (hazard ratio per SD TTR (4.8 mg/dL) = 0.97; 95% confidence interval: 0.94-1.00). Among those later diagnosed with ADRD, there was a marginally steeper downward TTR trajectory than those free of ADRD over follow-up (P=0.050). Our findings suggest TTR is not neuroprotective. The relative decline in TTR level in the preclinical stage of ADRD is likely to be a consequence of disease processes.
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