ArticleEuropean radiology2021
Skeletal muscle fat quantification by dual-energy computed tomography in comparison with 3T MR imaging.
Article in European radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 42 citations in OpenAlex.
- Effects of liraglutide or lifestyle interventions combined with other antidiabetic drugs on abdominal fat distribution in people with obesity and type 2 diabetes mellitus evaluated by the energy spectrum ct: A prospective randomized controlled study.Frontiers in endocrinology · 2022Trial
- Photon-counting CT for paraspinal muscle fat quantification compared with MRI proton density fat fraction.BMC medical imaging · 2026Article
- Clinical significance and future applications of standardized imaging parameters for assessing paraspinal muscle fatty infiltration in lumbar degenerative disease: a narrative review.Journal of orthopaedic surgery and research · 2026Review
- Sarcopenia and recurrence risk in high-risk non-muscle-invasive bladder cancer: a nonlinear modeling approach.The journal of nutrition, health & aging · 2026Article
- Validity of DEXA-Derived Thigh Muscle Quantification Against AI-Assisted CT: Inter-Limb Asymmetry Provides Superior Agreement over Absolute Values.Journal of clinical medicine · 2026Article
- Quantitative CT-derived small pulmonary vessel and erector spinae muscle parameters associated with acute exacerbation in COPD patients from a cold region: a dual-center study.Frontiers in medicine · 2026Article
- Opportunistic computed tomography assessment of bone, muscle, and adipose tissue: evidence, limitations, and clinical translation.Frontiers in medicine · 2026Review
- Sarcopenia in type 2 diabetes mellitus: an imaging review.Frontiers in medicine · 2026Review
- Changes of water and muscle content in lumbar paraspinal muscle degeneration and gender differences during aging using dual-energy CT.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Prognostic significance of preoperative abdominal fat thickness for pancreatic ductal adenocarcinoma.Discover oncology · 2025Article
- Differences in muscle morphology assessed by ultrasound at various muscle regions and their impact on voluntary and involuntary force production.Scientific reports · 2025Article
- Characteristics of mDIXON-Quant and proton magnetic resonance spectroscopy imaging of thigh skeletal muscles in patients with stroke-related sarcopenia: a prospective case-control study.Journal of Yeungnam medical science · 2025Article
- Dual-Energy CT muscle fat fraction as a new imaging biomarker of body composition and survival predictor in critically ill patients.European radiology · 2024Article
- Myosteatosis: diagnostic significance and assessment by imaging approaches.Quantitative imaging in medicine and surgery · 2024Review
- Role of effective atomic number of paraspinal muscles in the prediction of acute vertebral fracture risk assessment: a cross-sectional case-control study.The British journal of radiology · 2024Article
- What to Expect (and What Not) from Dual-Energy CT Imaging Now and in the Future?Journal of imaging · 2024Review
- SAROS: A dataset for whole-body region and organ segmentation in CT imaging.Scientific data · 2024Article
- Dual-energy CT applications in musculoskeletal disorders.The British journal of radiology · 2024Article
- Fat quantification in dual-layer detector spectral CT: How to handle iron overload, varying tube voltage and radiation dose Indices.PloS one · 2024Article
- Fat quantification of the rotator cuff muscles using CT histogram analysis in comparison with Dixon MRI sequence.The British journal of radiology · 2023Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo quantify the proportion of fat within the skeletal muscle as a measure of muscle quality using dual-energy CT (DECT) and to validate this methodology with MRI.
methodsTwenty-one patients with abdominal contrast-enhanced DECT scans (100 kV/Sn 150 kV) underwent abdominal 3-T MRI. The fat fraction (DECT-FF), determined by material decomposition, and HU values on virtual non-contrast-enhanced (VNC) DECT images were measured in 126 regions of interest (≥ 6 cm
resultsThe correlation was excellent between DECT-FF and MR-FF (r = 0.91), DECT VNC HU and MR-FF (r = - 0.90), and DECT-FF and DECT VNC HU (r = - 0.98). Intraclass correlation between DECT-FF and MR-FF was good (r = 0.83 [95% CI 0.71-0.90]), with a mean difference of - 0.15% (SD 3.32 [95% CI 6.35 to - 6.66]). Categorization using the SMRA yielded an eightfold difference in DECT VNC HU values between both groups (5 HU [95% CI 23-11], 42 HU [95% CI 33-56], p = 0.05). No significant relationship between DECT-FF and SMI-based classifications was observed.
conclusionsFat quantification within the skeletal muscle using DECT is both feasible and reliable. DECT muscle analysis offers a new approach to determine muscle quality, which is important for the diagnosis and therapeutic monitoring of sarcopenia, as a comorbidity associated with poor clinical outcome. KEY POINTS: • Dual-energy CT (DECT) material decomposition and virtual non-contrast-enhanced DECT HU values assess muscle fat reliably. • Virtual non-contrast-enhanced dual-energy CT HU values allow to differentiate between high and low native skeletal muscle mean radiation attenuation in contrast-enhanced DECT scans. • Measuring muscle fat by dual-energy computed tomography is a new approach for the determination of muscle quality, an important parameter for the diagnostic confirmation of sarcopenia as a comorbidity associated with poor clinical outcome.
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