ArticlePloS one2021
Antimicrobial activities evaluation and phytochemical screening of some selected medicinal plants: A possible alternative in the treatment of multidrug-resistant microbes.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
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Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Medicinal Plants Used for Combating Human Bacterial Diseases in Ethiopia: A Systematic Review.TheScientificWorldJournal · 2026Pooled it
- Antibacterial effect of chamomile extract irrigant activated with diode laser against Enterococcus faecalis.Lasers in medical science · 2026Article
- Metabolic engineering of tobacco plants using Carica papaya NAC transcription factors: a biotechnology tool to improve plant metabolite production.Biotechnology letters · 2026Article
- Plant-part specific in vitro antibacterial activity of crude ethanolic extracts of Mangifera indica against Salmonella typhi: an exploratory study.BMC complementary medicine and therapies · 2026Article
- Antioxidant, anticoccidial, and toxicological evaluation of Ocimum gratissimum and Vernonia amygdalina leaf extracts against Eimeria spp.Scientific reports · 2026Article
- Ethnobotanical importance and bioactivity of wild herbal teas from District Poonch Azad Jammu and Kashmir.Scientific reports · 2026Article
- Article
- Phenotypic high-content screening identifies plant-derived extracts targeting microbial growth, biofilms and swarming activity.Frontiers in microbiology · 2026Article
- Phytochemistry and insecticidal activity of six local plant extracts against Sitotroga Cerealella (Oliv.) (Lepidoptera: Gelechiidae) in stored wheat.BMC plant biology · 2025Article
- Isolation and In Vitro Pharmacological Evaluation of Phytochemicals from Medicinal Plants Traditionally Used for Respiratory Infections in Limpopo Province.Antibiotics (Basel, Switzerland) · 2025Article
- Article
- Advancements in Antimicrobial Surface Coatings Using Metal/Metaloxide Nanoparticles, Antibiotics, and Phytochemicals.Nanomaterials (Basel, Switzerland) · 2025Review
- Reviving the past for a healthier future: ancient molecules and remedies as a solution to the antibiotic crisis.Future microbiology · 2025Review
- Article
- Article
- Medicinal plants: bioactive compounds, biological activities, combating multidrug-resistant microorganisms, and human health benefits - a comprehensive review.Frontiers in immunology · 2025Review
- Correlation between antibacterial activities of twoJournal of biological methods · 2025Article
- In silico identification of phytoconstituents fromIn silico pharmacology · 2025Article
- Antibacterial and cytotoxic activities of different solvent extracts fromContemporary oncology (Poznan, Poland) · 2025Article
- Article
3 more citing papers are in PubMed but not listed here.
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundFour out of five individuals rely on traditional medicine for their primary healthcare needs. Medicinal plants are endowed with diverse bioactive compounds to treat multidrug-resistant (MDR) microbes. So far, a less thorough examination has been made in this regard. This study aimed to evaluate antimicrobial activity and phytochemical screening of selected medicinal plants against MDR microbes.
methodsIn vitro experimental study was carried out to evaluate antimicrobial effects and phytochemical screening of Rumex abyssinicus, Cucumis pustulatus, Discopodium penninervium, Lippia adoensis, Euphorbia depauperata, Cirsium englerianum, and Polysphaeria aethiopica against MDR bacteria and fungi. Aqueous and 80% methanolic extraction methods were employed for extraction. The susceptibility test, minimum inhibitory concentration, and minimum bactericidal or fungicidal concentration were measured using disc diffusion or broth micro-dilution as per the CLSI protocols.
resultThe 80% methanolic extraction method was a preferred method to aqueous. The phytochemical constituents identified were alkaloids, flavonoids, saponins, phenolic, tannins, terpenoidss, and cardiac glycosides. The hydroalcoholic extract demonstrated an appreciable antimicrobial role against MDR microbes with an MIC value of 1.0-128.0μg/ml and 11-29mm inhibition zone (IZ) in diameter. Extracts obtained from C. englerianum and E. depauperata showed a significant IZ ranged of 26-29mm on MRSA and Streptococcus pyogenes. MDR E. coli and K. pneumoniae showed 12-25mm and 23-28mm IZ in diameter, respectively. T. mentagraphytes was susceptible to all tested extracts. Moreover, S. pyogenes and K. pneumoniae were found the most susceptible bacteria to C. englerianum. Cirsium englerianum, L. adoensis, D. penninervium, and R. abyssinicus demonstrated remarkable antifungal effect against C. albicans and T. mentagrophytes, while R. abyssinicus showed the leading antifungal effect with 32 to 64μg/ml MIC values.
conclusionThe plant extracts have shown appreciable antimicrobial activities comparable to the currently prescribed modern drugs tested. Accordingly, further studies on clinical efficacy trial, safety, toxicity and affordability analyses have to be instigated promptly, so as to head to the final step to synthesize precursor molecules for new effective antimicrobials.
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