ArticlePLoS genetics2021
Drivers of linkage disequilibrium across a species' geographic range.
Article in PLoS genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed.
- Genetic architecture and candidate loci associated with growth and yield-related traits in sweet fig banana (Musa acuminata cv Sotoumon, AA).BMC genomics · 2026Article
- Population genomic signatures of founding events in autonomously self-fertilizing plants: a test with Impatiens capensis.The New phytologist · 2026Article
- Surviving the Squeeze: Genomic Analysis of a Successful Invasion by European Common Wall Lizards (Podarcis muralis) in North America (Ohio, USA).Molecular ecology · 2026Article
- Genomic implications of the repeated shift to self-fertilization across a species' geographic distribution.The Journal of heredity · 2025Article
- Unveiling the Genome-Wide Consequences of Range Expansion and Mating System Transitions in Primula vulgaris.Genome biology and evolution · 2024Article
- Coupling of Barriers to Gene Exchange: Causes and Consequences.Cold Spring Harbor perspectives in biology · 2024Review
- Allele surfing causes maladaptation in a Pacific salmon of conservation concern.PLoS genetics · 2023Article
- First genome-wide data from Italian European beech (Fagus sylvatica L.): Strong and ancient differentiation between Alps and Apennines.PloS one · 2023Article
- Recent speciation associated with range expansion and a shift to self-fertilization in North American Arabidopsis.Nature communications · 2022Article
- A functional genomics approach in Tanzanian population identifies distinct genetic regulators of cytokine production compared to European population.American journal of human genetics · 2022Article
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
While linkage disequilibrium (LD) is an important parameter in genetics and evolutionary biology, the drivers of LD remain elusive. Using whole-genome sequences from across a species' range, we assessed the impact of demographic history and mating system on LD. Both range expansion and a shift from outcrossing to selfing in North American Arabidopsis lyrata were associated with increased average genome-wide LD. Our results indicate that range expansion increases short-distance LD at the farthest range edges by about the same amount as a shift to selfing. However, the extent over which LD in genic regions unfolds was shorter for range expansion compared to selfing. Linkage among putatively neutral variants and between neutral and deleterious variants increased to a similar degree with range expansion, providing support that genome-wide LD was positively associated with mutational load. As a consequence, LD combined with mutational load may decelerate range expansions and set range limits. Finally, a small number of genes were identified as LD outliers, suggesting that they experience selection by either of the two demographic processes. These included genes involved in flowering and photoperiod for range expansion, and the self-incompatibility locus for mating system.
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