ArticleAmerican journal of physiology. Heart and circulatory physiology2021
Racial and socioeconomic disparity associates with differences in cardiac DNA methylation among men with end-stage heart failure.
Article in American journal of physiology. Heart and circulatory physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- DNA methylation and cardiovascular disease in humans: a systematic review and database of known CpG methylation sites.Clinical epigenetics · 2023Pooled it
- Nutritional Epigenetics of Vitamin Intake (A, BNutrients · 2026Article
- Global and regional DNA methylation patterns in heart failure: a case-control analysis.EBioMedicine · 2026Article
- Cardiac epigenome in heart development and disease.Nature reviews. Cardiology · 2026Review
- Artificial Intelligence Design for Race-Based Prostate Cancer Stage Classification With Multilayer Perceptron: Feature Selection Optimization Approach.JMIR formative research · 2026Article
- A pilot study on DNA methylation changes for non-invasive molecular diagnostics in heart failure.ESC heart failure · 2025Observational
- Clinical Thresholds for Visceral Adiposity Accumulation: A Comparative Analysis in Sex-, Age-, and BMI-Matched Black and White Adults.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Guidelines for mechanistic modeling and analysis in cardiovascular research.American journal of physiology. Heart and circulatory physiology · 2024Review
- Salt Sensitivity of Blood Pressure in Black People: The Need to Sort Out Ancestry Versus Epigenetic Versus Social Determinants of Its Causation.Hypertension (Dallas, Tex. : 1979) · 2024Review
- Genes, environment, and African ancestry in cardiometabolic disorders.Trends in endocrinology and metabolism: TEM · 2023Review
- Indirect epigenetic testing identifies a diagnostic signature of cardiomyocyte DNA methylation in heart failure.Basic research in cardiology · 2023Article
- Impact of Socioeconomic Status on Heart Failure.Journal of community hospital internal medicine perspectives · 2023Review
- An integrative framework and recommendations for the study of DNA methylation in the context of race and ethnicity.Discover social science and health · 2023Review
- Embedded racism: Inequitable niche construction as a neglected evolutionary process affecting health.Evolution, medicine, and public health · 2023Review
- A biosocial return to race? A cautionary view for the postgenomic era.American journal of human biology : the official journal of the Human Biology Council · 2022Review
- Editorial: DNA Methylation Dynamics and Human Diseases.Frontiers in cell and developmental biology · 2022Article
- Distinguishable DNA methylation defines disease susceptibility influenced by race and ethnicity.Clinical epigenetics · 2021Article
- Delineating racial and socioeconomic-related health disparities in end-stage heart failure: insight from cardiac DNA methylation.American journal of physiology. Heart and circulatory physiology · 2021Article
Corrections and comments
- Commented on by
Authors and funding
11 authors.
Funding
Abstract
Heart failure (HF) is a multifactorial syndrome that remains a leading cause of worldwide morbidity. Despite its high prevalence, only half of patients with HF respond to guideline-directed medical management, prompting therapeutic efforts to confront the molecular underpinnings of its heterogeneity. In the current study, we examined epigenetics as a yet unexplored source of heterogeneity among patients with end-stage HF. Specifically, a multicohort-based study was designed to quantify cardiac genome-wide cytosine-p-guanine (CpG) methylation of cardiac biopsies from male patients undergoing left ventricular assist device (LVAD) implantation. In both pilot (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.