ArticleEnvironmental microbiology2022
Oxidation of organoarsenicals and antimonite by a novel flavin monooxygenase widely present in soil bacteria.
Article in Environmental microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- Synergistic function of ars genes in arsenic detoxification and biosynthesis of organoarsenicals.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- Flavin-dependent enzymatic and photochemical interconversions between phenylarsonic and phenylarsonous acids.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Recent Advances in Transcriptome Analysis Within the Realm of Low Arsenic Rice Breeding.Plants (Basel, Switzerland) · 2025Review
- Genome Deletions and Rewiring of the Transcriptome Underlying High Antimonite Resistance inInternational journal of molecular sciences · 2024Article
- Adaptation to metal(loid)s in strain Mucilaginibacter rubeus P2 involves novel arsenic resistance genes and mechanisms.Journal of hazardous materials · 2024Article
- Widespread Distribution of theEnvironmental science & technology · 2023Article
- The ArsQ permease and transport of the antibiotic arsinothricin.Molecular microbiology · 2023Article
- Genomic Survey of Flavin Monooxygenases in Wild and Cultivated Rice Provides Insight into Evolution and Functional Diversities.International journal of molecular sciences · 2023Article
- ArsZ from Ensifer adhaerens ST2 is a novel methylarsenite oxidase.Environmental microbiology · 2022Article
- As(III) Exposure Induces a Zinc Scarcity Response and Restricts Iron Uptake in High-Level Arsenic-Resistant Paenibacillus taichungensis Strain NC1.Applied and environmental microbiology · 2022Article
- Glutathione Is Involved in the Reduction of Methylarsenate to Generate Antibiotic Methylarsenite in Enterobacter sp. Strain CZ-1.Applied and environmental microbiology · 2022Article
- Organoarsenical tolerance in Sphingobacterium wenxiniae, a bacterium isolated from activated sludge.Environmental microbiology · 2022Article
- Functional characterization of the methylarsenite-inducible arsRM operon from Noviherbaspirillum denitrificans HC18.Environmental microbiology · 2022Article
- ArsV and ArsW provide synergistic resistance to the antibiotic methylarsenite.Environmental microbiology · 2021Article
- Identification of a MarR Subfamily That Regulates Arsenic Resistance Genes.Applied and environmental microbiology · 2021Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
Arsenic can be biomethylated to form a variety of organic arsenicals differing in toxicity and environmental mobility. Trivalent methylarsenite (MAs(III)) produced in the methylation process is more toxic than inorganic arsenite (As(III)). MAs(III) also serves as a primitive antibiotic and, consequently, some environmental microorganisms have evolved mechanisms to detoxify MAs(III). However, the mechanisms of MAs(III) detoxification are not well understood. In this study, we identified an arsenic resistance (ars) operon consisting of three genes, arsRVK, that contribute to MAs(III) resistance in Ensifer adhaerens ST2. ArsV is annotated as an NADPH-dependent flavin monooxygenase with unknown function. Expression of arsV in the arsenic hypersensitive Escherichia coli strain AW3110Δars conferred resistance to MAs(III) and the ability to oxidize MAs(III) to MAs(V). In the presence of NADPH and either FAD or FMN, purified ArsV protein was able to oxidize both MAs(III) to MAs(V) and Sb(III) to Sb(V). Genes with arsV-like sequences are widely present in soils and environmental bacteria. Metagenomic analysis of five paddy soils showed the abundance of arsV-like sequences of 0.12-0.25 ppm. These results demonstrate that ArsV is a novel enzyme for the detoxification of MAs(III) and Sb(III) and the genes encoding ArsV are widely present in soil bacteria.
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Registered trials
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