SynthesisHuman brain mapping2021
Abnormalities of intrinsic brain activity in essential tremor: A meta-analysis of resting-state functional imaging.
Synthesis in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Abnormalities of intrinsic brain activity in late-life depression: a meta-analysis of resting-state functional imaging studies.Translational psychiatry · 2026Pooled it
- Spontaneous brain activity abnormalities in migraine: A meta-analysis of functional neuroimaging.Human brain mapping · 2023Pooled it
- Aberrant resting-state brain activity in Huntington's disease: A voxel-based meta-analysis.Frontiers in neurology · 2023Pooled it
- Abnormalities of intrinsic brain activity in essential tremor: A meta-analysis of resting-state functional imaging.Human brain mapping · 2021Pooled it
- Sodium Oxybate in Alcohol-Responsive Essential Tremor of Voice: An Open-Label Phase II Study.Movement disorders : official journal of the Movement Disorder Society · 2023Trial
- Thalamic and Visual Network Dysfunction Relates to Tremor Response in Thalamic Deep Brain Stimulation.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025Article
- Neuropathological characteristics of abnormal white matter functional signaling in adolescents with major depression.World journal of psychiatry · 2024Article
- Deep brain stimulation does not modulate resting-state functional connectivity in essential tremor.Brain communications · 2024Article
- Differences in Olivo-Cerebellar Circuit and Cerebellar Network Connectivity in Essential Tremor: a Resting State fMRI Study.Cerebellum (London, England) · 2023Article
- Mapping Essential Tremor to a Common Brain Network Using Functional Connectivity Analysis.Neurology · 2023Review
- Disrupted local functional connectivity in schizophrenia: An updated and extended meta-analysis.Schizophrenia (Heidelberg, Germany) · 2022Article
- Brain functional network abnormalities in parkinson's disease with mild cognitive impairment.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Combined brain network topological metrics with machine learning algorithms to identify essential tremor.Frontiers in neuroscience · 2022Article
- Psychoradiological abnormalities in treatment-naive noncomorbid patients with posttraumatic stress disorder.Depression and anxiety · 2022Article
- Topologically convergent and divergent morphological gray matter networks in early-stage Parkinson's disease with and without mild cognitive impairment.Human brain mapping · 2021Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroimaging studies using a variety of techniques have demonstrated abnormal patterns of spontaneous brain activity in patients with essential tremor (ET). However, the findings are variable and inconsistent, hindering understanding of underlying neuropathology. We conducted a meta-analysis of whole-brain resting-state functional neuroimaging studies in ET compared to healthy controls (HC), using anisotropic effect-size seed-based d mapping, to identify the most consistent brain activity alterations and their relation to clinical features. After systematic literature search, we included 13 studies reporting 14 comparisons, describing 286 ET patients and 254 HC. Subgroup analyses were conducted considering medication status, head tremor status, and methodological factors. Brain activity in ET is altered not only in the cerebellum and cerebral motor cortex, but also in nonmotor cortical regions including prefrontal cortex and insula. Most of the results remained unchanged in subgroup analyses of patients with head tremor, medication-naive patients, studies with statistical threshold correction, and the large subgroup of studies using functional magnetic resonance imaging. These findings not only show consistent and robust abnormalities in specific brain regions but also provide new information on the biology of patient heterogeneity, and thus help to elucidate the pathophysiology of ET.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.