Trial reportJournal of medical Internet research2021
Blended Acceptance and Commitment Therapy Versus Face-to-face Cognitive Behavioral Therapy for Older Adults With Anxiety Symptoms in Primary Care: Pragmatic Single-blind Cluster Randomized Trial.
Trial report in Journal of medical Internet research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Comparative effectiveness of non-pharmacological interventions on depression and anxiety in aging populations: a systematic review and network meta-analysis of randomized controlled trials.Frontiers in psychiatry · 2026Pooled it
- Acceptance and commitment therapy among caregivers of people with cancer: a systematic review and meta-analysis.Scientific reports · 2025Pooled it
- Cognitive behavioural therapy and third-wave approaches for anxiety and related disorders in older people.The Cochrane database of systematic reviews · 2024Pooled it
- Efficacy of Internet-Based Acceptance and Commitment Therapy for Depressive Symptoms, Anxiety, Stress, Psychological Distress, and Quality of Life: Systematic Review and Meta-analysis.Journal of medical Internet research · 2022Pooled it
- Evaluation of Two Web-Based Interventions (REMOTION and Res-Up!) for Clients From Psychotherapy Waitlists in Routine Outpatient Psychotherapy (Therapy Online Plus-TOP): Randomized Controlled Trial.Journal of medical Internet research · 2026Trial
- Trial
- Non-pharmacological treatment of anxiety in general practice: a scoping review.Scandinavian journal of primary health care · 2026Article
- The present and future of blended care: current research and introduction to the B-FIT framework.NPJ digital medicine · 2026Review
- Designing digital mental health interventions for older adults: a scoping review.NPJ digital medicine · 2026Article
- Article
- Testing the Feasibility, Acceptability, and Potential Efficacy of an Innovative Digital Mental Health Care Delivery Model Designed to Increase Access to Care: Open Trial of the Digital Clinic.JMIR mental health · 2025Article
- Blended Psychological Therapy for the Treatment of Psychological Disorders in Adult Patients: Systematic Review and Meta-Analysis.Interactive journal of medical research · 2024Review
- Increasing Older Adults' Social Connectedness: Development and Implementation of a Web-Assisted Acceptance and Commitment Therapy-Based Intervention.JMIR aging · 2024Article
- Evaluation of Two Web-Based Interventions (Res-Up! and REMOTION) in Routine Outpatient Psychotherapy (Therapy Online Plus-TOP): Protocol for a Randomized Controlled Trial.JMIR research protocols · 2023Article
- An overview of and recommendations for more accessible digital mental health services.Nature reviews psychology · 2022Article
- Is acceptance and commitment therapy helpful in reducing anxiety symptomatology in people aged 65 or over? A systematic review.Frontiers in psychiatry · 2022Review
- Digital health for allergen immunotherapy.Allergologie select · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnxiety symptoms in older adults are prevalent and disabling but often go untreated. Most trials on psychological interventions for anxiety in later life have examined the effectiveness of face-to-face cognitive behavioral therapy (CBT). To bridge the current treatment gap, other treatment approaches and delivery formats should also be evaluated.
objectiveThis study is the first to examine the effectiveness of a brief blended acceptance and commitment therapy (ACT) intervention for older adults with anxiety symptoms, compared with a face-to-face CBT intervention.
methodsAdults aged between 55-75 years (n=314) with mild to moderately severe anxiety symptoms were recruited from general practices and cluster randomized to either blended ACT or face-to-face CBT. Assessments were performed at baseline (T0), posttreatment (T1), and at 6- and 12-month follow-ups (T2 and T3, respectively). The primary outcome was anxiety symptom severity (Generalized Anxiety Disorder-7). Secondary outcomes were positive mental health, depression symptom severity, functional impairment, presence of Diagnostic and Statistical Manual of Mental Disorders V anxiety disorders, and treatment satisfaction.
resultsConditions did not differ significantly regarding changes in anxiety symptom severity during the study period (T0-T1: B=.18, P=.73; T1-T2: B=-.63, P=.26; T1-T3: B=-.33, P=.59). Large reductions in anxiety symptom severity (Cohen d≥0.96) were found in both conditions post treatment, and these were maintained at the 12-month follow-up. The rates of clinically significant changes in anxiety symptoms were also not different for the blended ACT group and CBT group (χ
conclusionsThe results show that blended ACT is a valuable treatment alternative to CBT for anxiety in later life.
trial registrationNetherlands Trial Register TRIAL NL6131 (NTR6270); https://www.trialregister.nl/trial/6131.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.