ArticleeLife2021
Acquisition of innate odor preference depends on spontaneous and experiential activities during critical period.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Olfactory Valence-Processing Deficits and Aberrant Brain Network Connectivity Underlie Social Dysfunction in Shank3Neuroscience bulletin · 2026Article
- A microbiome-derived olfactory signal regulates inter-male aggression and social dominance in mice.Current biology : CB · 2026Article
- Foxg1 Defines Ventrolateral Zonal Identity by Sustaining Neurogenic Progenitor Potential in the Olfactory Epithelium.Genes to cells : devoted to molecular & cellular mechanisms · 2026Article
- Fat sensory cues in early life program central response to food and obesity.Nature metabolism · 2025Article
- Dopaminergic short axon cells integrate sensory and top-down inputs to enhance discriminative learning in the mouse olfactory bulb.PLoS biology · 2025Article
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- How early olfactory experiences influence brain development in mice.Frontiers in neural circuits · 2025Review
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- Molecular, Cellular, and Developmental Organization of the Mouse Vomeronasal organ at Single Cell Resolution.bioRxiv : the preprint server for biology · 2024Article
- Distinct subpopulations of ventral pallidal cholinergic projection neurons encode valence of olfactory stimuli.Cell reports · 2024Article
- Activity-dependent formation of the topographic map and the critical period in the development of mammalian olfactory system.Genesis (New York, N.Y. : 2000) · 2024Review
- Circuit formation and sensory perception in the mouse olfactory system.Frontiers in neural circuits · 2024Review
- The frontal sharp transient in newborns: An endogenous neurobiomarker concomitant to the physiological and critical transitional period around delivery?Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Neuronal excitability as a regulator of circuit remodeling.Current biology : CB · 2023Article
- Article
- More than meets the AI: The possibilities and limits of machine learning in olfaction.Frontiers in neuroscience · 2022Review
- Food preference acquired by social transmission is altered by the absence of the olfactory marker protein in mice.Frontiers in nutrition · 2022Article
- A physicochemical model of odor sampling.PLoS computational biology · 2021Article
- Encoding innately recognized odors via a generalized population code.Current biology : CB · 2021Article
- Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Animals possess an inborn ability to recognize certain odors to avoid predators, seek food, and find mates. Innate odor preference is thought to be genetically hardwired. Here we report that acquisition of innate odor recognition requires spontaneous neural activity and is influenced by sensory experience during early postnatal development. Genetic silencing of mouse olfactory sensory neurons during the critical period has little impact on odor sensitivity, discrimination, and recognition later in life. However, it abolishes innate odor preference and alters the patterns of activation in brain centers. Exposure to innately recognized odors during the critical period abolishes the associated valence in adulthood in an odor-specific manner. The changes are associated with broadened projection of olfactory sensory neurons and expression of axon guidance molecules. Thus, a delicate balance of neural activity is needed during the critical period in establishing innate odor preference and convergent axon input is required to encode innate odor valence.
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