Evidence map›Paper›PMID 33769277›Full record

Observational studyInternational journal of clinical pharmacology and therapeutics2021

Genomic markers associated with successful treatment of hypertension with lisinopril: A pilot study.

Hania K Flaten, Brandon J Sonn, Jessica L Saben, Shelby K Shelton, John Schwartz, Karen Ryall, Andrew A Monte

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International journal of clinical pharmacology and therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hania K Flaten
Brandon J Sonn
Jessica L Saben
Shelby K Shelton
John Schwartz
Karen Ryall
Andrew A Monte

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
PERSONALIZING EMERGENCY/ACUTE THERAPEUTICS UTILIZING SYSTEMS BIOLOGY (PEGASUS)R35GM124939 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI MONTE, ANDREW ALBERT · 2017 to 2021
$2.1M
NCATS NIH HHS UL1 TR002535NIGMS NIH HHS R35 GM124939
6 · The paper itself

Abstract

objectiveTo identify single nucleotide variants (SNVs) associated with lisinopril effectiveness. MATERIALS AND

methodsThis was an observational study using a candidate gene approach to examine SNVs associated with lisinopril effectiveness. Drug effectiveness was defined as 10% decrease in systolic blood pressure at 1 week follow-up. We used the Illumina GWAS MEGA chip to examine variants in the renin/angiotensin pathway that may be associated with drug effectiveness.

results61 subjects were enrolled, and 33 (54.1%) were responsive to lisinopril therapy. SNVs in

Indexed as

HypertensionLisinoprilAngiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsBlood PressureGenomicsHumansPilot ProjectsRenin-Angiotensin SystemAngiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsLisinopril

Identifiers

PMID33769277
PMCPMC8383846
OpenAlexW3137517283

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.