ArticleAJOB neuroscience
Mapping the Ethical Issues of Brain Organoid Research and Application.
Article in AJOB neuroscience. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Organoids: a systematic review of ethical issues.Stem cell research & therapy · 2022Pooled it
- Emerging organoids and organoids-on-chip platforms for translational development of antibody‒drug conjugates and next-generation bioconjugates.Acta pharmaceutica Sinica. B · 2026Review
- Ethics and Regulation of Human Brain Organoid Research: Recommendations from the Asia Pacific Neuroethics Working Group.Asian bioethics review · 2026Article
- Manipulating embryogenesis and testing for potential: two real problems for the regulation of stem cell-based embryo models.Journal of medical ethics · 2026Article
- Ethical concerns about embodied brain organoids shaped by foundational distinctions and perceptions of consciousness.Scientific reports · 2026Article
- Integrating neural organoids and AI: increasing the risk of artificial consciousness or medical malpractice?Frontiers in molecular neuroscience · 2026Article
- Japanese attitudes toward human brain organoid research: broad support amid ethical concerns.Frontiers in genetics · 2026Article
- The ethical aspects of human organ-on-chip models: A mapping review.Stem cell reports · 2025Review
- Harnessing Intelligence from Brain Cells In Vitro.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2025Review
- Facing the possibility of consciousness in human brain organoids.Patterns (New York, N.Y.) · 2025Review
- An overview of stem cells and cell products involved in trauma injury.Regenerative therapy · 2025Review
- Moral Intuition Regarding the Possibility of Conscious Human Brain Organoids: An Experimental Ethics Study.Science and engineering ethics · 2024Article
- Human Brain Organoid Research and Applications: Where and How to Meet Legal Challenges?Journal of bioethical inquiry · 2024Review
- The Ethics of Stem Cell-Based Embryo-Like Structures : A Focus Group Study on the Perspectives of Dutch Professionals and Lay Citizens.Journal of bioethical inquiry · 2024Article
- Neuroethics and AI ethics: a proposal for collaboration.BMC neuroscience · 2024Review
- East Asian perspective of responsible research and innovation in neurotechnology.IBRO neuroscience reports · 2024Article
- The ethical and legal challenges of human foetal brain tissue-derived organoids : At the intersection of science, ethics, and regulation.EMBO reports · 2024Article
- The Donation of Human Biological Material for Brain Organoid Research: The Problems of Consciousness and Consent.Science and engineering ethics · 2024Article
- Sentience, Vulcans, and zombies: the value of phenomenal consciousness.AI & society · 2024Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 2008, researchers created human three-dimensional neural tissue - known as the pioneering work of "brain organoids." In recent years, some researchers have transplanted human brain organoids into animal brains for applicational purposes. With these experiments have come many ethical concerns. It is thus an urgent task to clarify what is ethically permissible and impermissible in brain organoid research. This paper seeks (1) to sort out the ethical issues related to brain organoid research and application and (2) to propose future directions for additional ethical consideration and policy debates in the field. Toward (1), this paper first outlines the current state of brain organoid research, and then briefly responds to previously raised related ethical concerns. Looking next at anticipated scientific developments in brain organoid research, we will discuss (i) ethical issues related to in vitro brain organoids, (ii) ethical issues raised when brain organoids form complexes or have relationships with other entities, and (iii) ethical issues of research ethics and governance. Finally, in pursuit of (2), we propose research policies that are mindful of the ethics of brain organoid research and application and also suggest the need for an international framework for research and application of brain organoids.
Indexed as
Identifiers
33769221What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.