Evidence map›Paper›PMID 33769181›Full record

ArticleAnnals of medicine2021

Macrophages expressing TREM-1 are involved in the progression of HPV16-related oropharyngeal squamous cell carcinoma.

Barbara Azzimonti, Luca Raimondo, Diletta Francesca Squarzanti, Tiziana Rosso, Paola Zanetta, Paolo Aluffi Valletti, Luigi Chiusa, Laura Masini, Giancarlo Pecorari, Mario Airoldi and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Effects of macrophages in OSCC progression.Frontiers in immunology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Barbara AzzimontiCenter for Translational Research on Autoimmune and Allergic Diseases (CAAD), Department of Health Sciences (DiSS), University of Piemonte Orientale (UPO), Novara, Italy.ORCID 0000-0001-6364-6595
Luca RaimondoOtorhinolaryngology Division, Department of Surgical Sciences, University of Turin, Turin, Italy.
Diletta Francesca SquarzantiCenter for Translational Research on Autoimmune and Allergic Diseases (CAAD), Department of Health Sciences (DiSS), University of Piemonte Orientale (UPO), Novara, Italy.
Tiziana RossoClinical Epidemiology Unit, "Città della Salute e della Scienza" Hospital - CPO Piemonte, Torino, Italy.
Paola ZanettaCenter for Translational Research on Autoimmune and Allergic Diseases (CAAD), Department of Health Sciences (DiSS), University of Piemonte Orientale (UPO), Novara, Italy.
Paolo Aluffi VallettiDivision of Ear Nose and Throat Department-Head and Neck Surgery, DiSS, University of Piemonte Orientale (UPO), Novara, Italy.
Luigi ChiusaDepartment of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy.
Laura MasiniRadiotherapy Unit, Department of Translational Medicine (DiMeT), University of Piemonte Orientale (UPO), Novara, Italy.
Giancarlo PecorariOtorhinolaryngology Division, Department of Surgical Sciences, University of Turin, Turin, Italy.
Mario AiroldiDepartment of Oncology, Azienda Ospedaliera Universitaria Citta' della Salute e della Scienza di Torino, Turin, Italy.
Marco KrengliRadiotherapy Unit, Department of Translational Medicine (DiMeT), University of Piemonte Orientale (UPO), Novara, Italy.
Mirella GiovarelliDepartment of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy.ORCID 0000-0002-7397-3466
Guido ValentePathology Unit, Ospedale "Sant'Andrea", DiMeT, University of Piemonte Orientale (UPO), Vercelli, Italy.
Università degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITAzienda Ospedaliera Citta' della Salute e della Scienza di Torino · ITUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMany types of research have been performed to improve the diagnosis, therapy, and prognosis of oropharyngeal carcinomas (OP-SCCs). Since they arise in lymphoid-rich areas and intense lymphocytic infiltration has been related to a better prognosis, a TREM-1 putative function in tumour progression and survival has been hypothesized. MATERIALS AND

methodsTwenty-seven human papillomavirus (HPV) 16

resultsNo differences have been shown between intratumoral and stromal CD4

conclusionWhile p16 shows to better stratify HPV16

Indexed as

Human papillomavirus 16AdultAgedDisease ProgressionFemaleHead and Neck NeoplasmsHumansMacrophagesMaleMiddle AgedPapillomavirus InfectionsPrognosisRetrospective StudiesSquamous Cell Carcinoma of Head and NeckTriggering Receptor Expressed on Myeloid Cells-1Triggering Receptor Expressed on Myeloid Cells-1Human papillomavirus (HPV)oropharyngeal squamous cell carcinoma (OP-SCCs)peritumoral and intratumoral infiltrationtriggering receptor expressed on myeloid cells-1 (TREM-1)tumoral microenvironment (TME)

Identifiers

PMID33769181
PMCPMC8008925
OpenAlexW3136923739

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.