Evidence map›Paper›PMID 33769156›Full record

ArticleAIDS care2022

Antiretroviral therapy based HIV prevention targeting young women who sell sex: a mixed method approach to understand the implementation of PrEP in a rural area of KwaZulu-Natal, South Africa.

Natsayi Chimbindi, Nondumiso Mthiyane, Thembelihle Zuma, Kathy Baisley, Deenan Pillay, Nuala McGrath, Guy Harling, Lorraine Sherr, Isolde Birdthistle, Sian Floyd and 4 more

Abstract read
In one paragraph

Article in AIDS care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  6. Experiences of adolescent girls and young women of oral PrEP uptake in rural KwaZulu-Natal.African journal of primary health care & family medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Natsayi ChimbindiAfrica Health Research Institute (AHRI), KwaZulu-Natal, South Africa.
Nondumiso MthiyaneAfrica Health Research Institute (AHRI), KwaZulu-Natal, South Africa.
Thembelihle ZumaAfrica Health Research Institute (AHRI), KwaZulu-Natal, South Africa.
Kathy BaisleyAfrica Health Research Institute (AHRI), KwaZulu-Natal, South Africa.
Deenan PillayInstitute for Global Health, University College London (UCL), London, UK.
Nuala McGrathAfrica Health Research Institute (AHRI), KwaZulu-Natal, South Africa.ORCID 0000-0002-1039-0159
Guy HarlingAfrica Health Research Institute (AHRI), KwaZulu-Natal, South Africa.
Lorraine SherrInstitute for Global Health, University College London (UCL), London, UK.ORCID 0000-0002-5902-8011
Isolde BirdthistleLondon School of Hygiene & Tropical Medicine, London, UK.
Sian FloydLondon School of Hygiene & Tropical Medicine, London, UK.
Jaco DreyerAfrica Health Research Institute (AHRI), KwaZulu-Natal, South Africa.
Sarah NakasoneUniversity of Chicago, Chicago, IL, USA.
Janet SeeleyAfrica Health Research Institute (AHRI), KwaZulu-Natal, South Africa.ORCID 0000-0002-0583-5272
Maryam ShahmaneshAfrica Health Research Institute (AHRI), KwaZulu-Natal, South Africa.ORCID 0000-0001-7129-8535

Funding

Maximizing combination HIV prevention, uptake and retention by adolescent girls and young womenR01MH114560 · NIMH · KWAZULU-NATAL RESEARCH INSTITUTE TB-HIV · PI SHAHMANESH, MARYAM · 2017 to 2023
$2.0M
Department of Health RP-2017-08-ST2-008Medical Research Council MR/R010161/1NIMH NIH HHS R01 MH114560Wellcome TrustWellcome Trust 082384/Z/07/Z
6 · The paper itself

Abstract

Pre-Exposure Prophylaxis (PrEP) is a potential game-changer for HIV. We used PrEP introduction for Young Women Who Sell Sex (YWSS) in a rural South Africa district to understand community norms and PrEP coverage in YWSS. Between 2017 and 2018, we measured awareness and uptake of PrEP in a representative cohort of 2184 Adolescent Girls and Young Women (AGYW) aged 13-22. We conducted group discussions with young people and community members (19); key informant interviews (9), in-depth interviews with 15-24 year-olds (58) and providers (33). Interviews were analysed using thematic analysis. PrEP awareness increased from 2% to 9%. Among 965 AGYW sexually-active by 2018, 13.4% (95%CI: 11.4%-15.7%) reported transactional sex and 10.6% (95%CI: 8.85-12.7%) sex for money. Of the 194 YWSS, 21 were aware of PrEP, but none had used it. Youth were enthusiastic about PrEP as tool for HIV prevention; whilst older community members were cautious about a technology they had limited experience with but could benefit select groups. Teachers and healthcare providers were concerned that PrEP would lower personal responsibility for sexual health. In conclusion, the narrow and limited introduction of PrEP to YWSS reduced the accessibility and reach. Introducing PrEP as part of sexual healthcare may improve demand and access for YWSS.

Indexed as

Anti-HIV AgentsHIV InfectionsPre-Exposure ProphylaxisAdolescentAdultCoitusFemaleHumansSexual BehaviorSouth AfricaYoung AdultAnti-HIV AgentsacceptabilityAccess frameworkadolescentsfemale-sex workersHIV prevention interventionspre-exposure prophylaxis (PrEP)young women who sell sex

Identifiers

PMID33769156
PMCPMC8464632

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.