ArticleJournal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
Neurobiology of Avoidant/Restrictive Food Intake Disorder in Youth with Overweight/Obesity Versus Healthy Weight.
Article in Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Brain structural and functional changes in childhood and adolescent obesity: a systematic review of MRI studies.Frontiers in human neuroscience · 2026Pooled it
- Physical health complications in children and young people with avoidant restrictive food intake disorder (ARFID): a systematic review and meta-analysis.BMJ paediatrics open · 2024Pooled it
- Clinical Phenotypes and Neurobiology of Youth With Avoidant/Restrictive Food Intake Disorder (ARFID) Across Sex.The International journal of eating disorders · 2026Article
- Serum Leptin in Youth and Young Adults With Avoidant/Restrictive Food Intake Disorder Across the Weight Spectrum.The International journal of eating disorders · 2026Article
- Annual Research Review: Neural mechanisms of eating disorders in youth - from current theory and findings to future directions.Journal of child psychology and psychiatry, and allied disciplines · 2026Review
- High prevalence of avoidant/restrictive food ıntake disorder and psychiatric comorbidities in pediatric eosinophilic esophagitis.European journal of pediatrics · 2026Article
- Psychopathology in Adults with Co-Occurring Avoidant/Restrictive Food Intake Disorder and Higher Weight.Psychotherapy and psychosomatics · 2026Article
- Multidisciplinary Approach to the Diagnosis of Avoidant/Restrictive Food Intake Disorder in Children with Autism Spectrum Disorder: A Multistage Mixed-Methods Study.Consortium psychiatricum · 2026Article
- Amygdala and insula activation in youth with avoidant/restrictive food intake disorder in response to aversive food-specific fear images.Psychological medicine · 2025Article
- EEG Resting-state Microstate Dynamics in Children and Adolescents with Avoidant/Restrictive Food Intake Disorder (ARFID).Brain topography · 2025Article
- Neural correlates of children with avoidant restrictive food intake disorder symptoms: large-scale neuroanatomical analysis of a paediatric population.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- Article
- Neural Response to Food Cues in Avoidant/Restrictive Food Intake Disorder.JAMA network open · 2025Article
- Empirical Approaches to the Classification of Avoidant/Restrictive Food Intake Disorder.The International journal of eating disorders · 2025Article
- Comparison of clinical presentation and management of children and adolescents with ARFID between paediatrics and child and adolescent psychiatry: a prospective surveillance study.Archives of disease in childhood · 2025Article
- Article
- Conceptualizing avoidant/restrictive food intake disorder via an executive functioning lens.The International journal of eating disorders · 2024Article
- Trajectory of ghrelin and PYY around a test meal in males and females with avoidant/restrictive food intake disorder versus healthy controls.Psychoneuroendocrinology · 2024Article
- Avoidant restrictive food intake disorder: recent advances in neurobiology and treatment.Journal of eating disorders · 2024Review
- The Sensory Profiles, Eating Behaviors, and Quality of Life of Children with Autism Spectrum Disorder and Avoidant/Restrictive Food Intake Disorder.The Psychiatric quarterly · 2024Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
Abstract
objectiveAvoidant/restrictive food intake disorder (ARFID) occurs across the weight spectrum, however research addressing the coexistesnce of ARFID with overweight/obesity (OV/OB) is lacking. We aimed to establish co-occurrence of OV/OB and ARFID and to characterize divergent neurobiological features of ARFID by weight.
methodYouth with full/subthreshold ARFID (12 with healthy weight [HW], 11 with OV/OB) underwent fasting brain fMRI scan while viewing food/non-food images (M age = 16.92 years, 65% female, 87% white). We compared groups on BOLD response to high-calorie foods (HCF) (vs. objects) in food cue processing regions of interest. Following fMRI scanning, we evaluated subjective hunger pre- vs. post-meal. We used a mediation model to explore the association between BMI, brain activation, and hunger.
resultsParticipants with ARFID and OV/OB demonstrated significant hyperactivation in response to HCF (vs. objects) in the orbitofrontal cortex (OFC) and anterior insula compared with HW participants with ARFID. Mediation analysis yielded a significant indirect effect of group (HW vs. OV/OB) on hunger via OFC activation (effect = 18.39, SE = 11.27, 95% CI [-45.09, -3.00]), suggesting that OFC activation mediates differences in hunger between ARFID participants with HW and OV/OB.
conclusionsCompared to youth with ARFID and HW, those with OV/OB demonstrate hyperactivation of brain areas critical for the reward value of food cues. Postprandial changes in subjective hunger depend on BMI and are mediated by OFC activation to food cues. Whether these neurobiological differences contribute to selective hyperphagia in ARFID presenting with OV/OB and represent potential treatment targets is an important area for future investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.