ArticleJournal of biophotonics2021
Photoacoustic imaging of in vivo hemodynamic responses to sodium nitroprusside.
Article in Journal of biophotonics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- A Novel Approach Combining Ultrasound-Induced Drug-Free Vasodilation and Photoacoustic Monitoring of Vascular Responses.Annals of biomedical engineering · 2026Article
- Platelet-mediated activation of perivascular mast cells triggers progression of sepsis to septic shock in mice.Nature communications · 2025Article
- Review on Photoacoustic Monitoring after Drug Delivery: From Label-Free Biomarkers to Pharmacokinetics Agents.Pharmaceutics · 2024Review
- Photoacoustic based evaluation of viscoelastic properties of Gram-negative and Gram-positive bacterial colonies.Scientific reports · 2023Article
- Hessian filter-assisted full diameter at half maximum (FDHM) segmentation and quantification method for optical-resolution photoacoustic microscopy.Biomedical optics express · 2022Article
- Real-time whole-brain imaging of hemodynamics and oxygenation at micro-vessel resolution with ultrafast wide-field photoacoustic microscopy.Light, science & applications · 2022Article
- Thin ceramic PZT dual- and multi-frequency pMUT arrays for photoacoustic imaging.Microsystems & nanoengineering · 2022Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
The in vivo hemodynamic impact of sodium nitroprusside (SNP), a widely used antihypertensive agent, has not been well studied. Here, we applied functional optical-resolution photoacoustic microscopy (OR-PAM) to study the hemodynamic responses to SNP in mice in vivo. As expected, after the application of SNP, the systemic blood pressure (BP) was reduced by 53%. The OR-PAM results show that SNP induced an arterial vasodilation of 24% and 23% in the brain and skin, respectively. A weaker venous vasodilation of 9% and 5% was also observed in the brain and skin, respectively. The results show two different types of blood oxygenation response. In mice with decreased blood oxygenation, the arterial and venous oxygenation was respectively reduced by 6% and 13% in the brain, as well as by 7% and 18% in the skin. In mice with increased blood oxygenation, arterial and venous oxygenation was raised by 4% and 22% in the brain, as well as by 1% and 9% in the skin. We observed venous change clearly lagged the arterial change in the skin, but not in the brain. Our results collectively show a correlation among SNP induced changes in systemic BP, vessel size and blood oxygenation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.