ArticleArthritis care & research2022
Magnetic Resonance Imaging-Defined Osteoarthritis Features and Anterior Knee Pain in Individuals With, or at Risk for, Knee Osteoarthritis: A Multicenter Study on Osteoarthritis.
Article in Arthritis care & research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 22 citations in OpenAlex.
- Insights into the complex relationship between pain and imaging-detected structural damage in knee osteoarthritis.Skeletal radiology · 2026Review
- Structural Gains Without Symptomatic Benefit After Microfracture During High Tibial Osteotomy.Orthopaedic journal of sports medicine · 2026Article
- Beyond the algorithms: Challenges in predicting knee osteoarthritis pain from a machine learning point of view.Osteoarthritis imaging · 2026Article
- Validity of DEXA-Derived Thigh Muscle Quantification Against AI-Assisted CT: Inter-Limb Asymmetry Provides Superior Agreement over Absolute Values.Journal of clinical medicine · 2026Article
- Increased tibial tubercle torsion is associated with advanced lateral patellofemoral osteoarthritis.Journal of experimental orthopaedics · 2026Article
- Microenvironmental response-based treatment of osteoarthritis is a highly effective and durable program: a review.Journal of orthopaedic surgery and research · 2025Review
- Imaging-based measures of synovitis in knee osteoarthritis: A scoping review and narrative synthesis.Osteoarthritis and cartilage open · 2025Review
- A machine learning-based radiomics approach for differentiating patellofemoral osteoarthritis from non-patellofemoral osteoarthritis using Q-Dixon MRI.Frontiers in sports and active living · 2025Article
- Dynamic Changes in Muscle Thickness and Infrapatellar Fat Pad During Quadriceps Setting: An Ultrasound Echo Analysis.Cureus · 2024Article
- The influence of patellar morphology on clinical outcomes after unicompartmental knee arthroplasty.International orthopaedics · 2024Article
- Planned or recent first consultation with the general practitioner for knee complaints: Is it indicative of early-stage knee osteoarthritis?Osteoarthritis and cartilage open · 2024Article
- Association between quadriceps fat pad edema and patellofemoral osteoarthritis: a quantitative Q-Dixon-based magnetic resonance imaging (MRI) analysis.Quantitative imaging in medicine and surgery · 2024Article
- Association between knee magnetic resonance imaging markers and knee symptoms over 6-9 years in young adults.Rheumatology (Oxford, England) · 2024Article
- Associations between anterior knee pain and 2-year patellofemoral cartilage worsening: The MOST study.Osteoarthritis and cartilage · 2024Article
- Anterior knee pain as a potential risk factor for falls in older adults: insights from the osteoarthritis initiative data.BMC public health · 2023Observational
- Association between infrapatellar fat pad ultrasound elasticity and anterior knee pain in patients with knee osteoarthritis.Scientific reports · 2023Article
- Update on recent developments in imaging of inflammation in osteoarthritis: a narrative review.Skeletal radiology · 2023Review
- The role of bone mineral density and cartilage volume to predict knee cartilage degeneration.European journal of translational myology · 2022Article
- Higher risk of knee arthroplasty during ten-year follow-up if baseline radiographic osteoarthritis involves the patellofemoral joint: a CHECK Cohort Study.BMC musculoskeletal disorders · 2022Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 3 countries.
Funding
Abstract
objectiveThe lack of strong association between knee osteoarthritis (OA) structural features and pain continues to perplex researchers and clinicians. Evaluating the patellofemoral joint in addition to the tibiofemoral joint alone has contributed to explaining this structure-pain discordance, hence justifying a more comprehensive evaluation of whole-knee OA and pain. The present study, therefore, was undertaken to evaluate the association between patellofemoral and tibiofemoral OA features with localized anterior knee pain (AKP) using 2 study designs.
methodsUsing cross-sectional data from the Multicenter Osteoarthritis Study, our first approach was a within-person, knee-matched design in which we identified participants with unilateral AKP. We then assessed magnetic resonance imaging (MRI)-derived OA features (cartilage damage, bone marrow lesions [BMLs], osteophytes, and inflammation) in both knees and evaluated the association of patellofemoral and tibiofemoral OA features to unilateral AKP. In our second approach, MRIs from 1 knee per person were scored, and we evaluated the association of OA features to AKP in participants with AKP and participants with no frequent knee pain.
resultsUsing the first approach (n = 71, 66% women, mean ± SD age 69 ± 8 years), lateral patellofemoral osteophytes (odds ratio [OR] 5.0 [95% confidence interval (95% CI) 1.7-14.6]), whole-knee joint effusion-synovitis (OR 4.7 [95% CI 1.3-16.2]), and infrapatellar synovitis (OR 2.8 [95% CI 1.0-7.8]) were associated with AKP. Using the second approach (n = 882, 59% women, mean ± SD age 69 ± 7 years), lateral and medial patellofemoral cartilage damage (prevalence ratio [PR] 2.3 [95% CI 1.3-4.0] and PR 1.9 [95% CI 1.1-3.3], respectively) and lateral patellofemoral BMLs (PR 2.6 [95% CI 1.5-4.7]) were associated with AKP.
conclusionPatellofemoral but not tibiofemoral joint OA features and inflammation were associated with AKP.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.