Evidence map›Paper›PMID 33768557›Full record

ArticleBiometrics2022

Inverse probability weighted estimators of vaccine effects accommodating partial interference and censoring.

Sujatro Chakladar, Samuel Rosin, Michael G Hudgens, M Elizabeth Halloran, John D Clemens, Mohammad Ali, Michael E Emch

Open access · greenAbstract read
In one paragraph

Article in Biometrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. G-estimation with partial interference.Stat (International Statistical Institute) · 2025
    Article
  3. Designs for Vaccine Studies.Annual review of statistics and its application · 2025
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Sujatro ChakladarDepartment of Biostatistics, University of North Carolina, Chapel Hill, North Carolina.ORCID 0000-0001-5321-6444
Samuel RosinDepartment of Biostatistics, University of North Carolina, Chapel Hill, North Carolina.ORCID 0000-0002-8089-4133
Michael G HudgensDepartment of Biostatistics, University of North Carolina, Chapel Hill, North Carolina.ORCID 0000-0002-9106-4194
M Elizabeth HalloranDepartment of Biostatistics, University of Washington, Seattle, Washington.ORCID 0000-0002-3127-1757
John D ClemensDepartment of Epidemiology, University of California, Los Angeles, California.
Mohammad AliDepartment of International Health, Johns Hopkins University, Baltimore, Maryland.
Michael E EmchDepartment of Geography, University of North Carolina, Chapel Hill, North Carolina.
University of North Carolina at Chapel Hill · USJohns Hopkins University · USUniversity of California, Los Angeles · USUniversity of Washington · US

Funding

Causal Inference in Infectious Disease Prevention StudiesR01AI085073 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HUDGENS, MICHAEL G · 2010 to 2024
$4.5M
Causal Inference in Infectious Disease Prevention StudiesR37AI085073 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Michael G Hudgens · 2026 to 2026
$394k
NIAID NIH HHS R01 AI085073NIAID NIH HHS R37 AI085073
6 · The paper itself

Abstract

Estimating population-level effects of a vaccine is challenging because there may be interference, that is, the outcome of one individual may depend on the vaccination status of another individual. Partial interference occurs when individuals can be partitioned into groups such that interference occurs only within groups. In the absence of interference, inverse probability weighted (IPW) estimators are commonly used to draw inference about causal effects of an exposure or treatment. Tchetgen Tchetgen and VanderWeele proposed a modified IPW estimator for causal effects in the presence of partial interference. Motivated by a cholera vaccine study in Bangladesh, this paper considers an extension of the Tchetgen Tchetgen and VanderWeele IPW estimator to the setting where the outcome is subject to right censoring using inverse probability of censoring weights (IPCW). Censoring weights are estimated using proportional hazards frailty models. The large sample properties of the IPCW estimators are derived, and simulation studies are presented demonstrating the estimators' performance in finite samples. The methods are then used to analyze data from the cholera vaccine study.

Indexed as

Cholera VaccinesComputer SimulationHumansModels, StatisticalProbabilityProportional Hazards ModelsSurvival AnalysisCholera Vaccinescausal inferenceinterferenceright censoringsurvival

Identifiers

PMID33768557
PMCPMC8463630
OpenAlexW3137098874

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.