ArticleMolecular imaging and biology2021
Performance Evaluation of SimPET-X, a PET Insert for Simultaneous Mouse Total-Body PET/MR Imaging.
Article in Molecular imaging and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Performance evaluation of the nanoScanEJNMMI physics · 2025Article
- [Advances in multimodal biomedical imaging of small animals].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025Review
- First performance evaluation of easyPET.3D, a high-resolution and cost-effective benchtop preclinical PET scanner.EJNMMI physics · 2025Article
- Submillimeter-Resolution PET for High-Sensitivity Mouse Brain Imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Performance evaluation of SimPET-L and SimPET-XL: MRI-compatible small-animal PET systems with rat-body imaging capability.EJNMMI physics · 2023Article
- Technical opportunities and challenges in developing total-body PET scanners for mice and rats.EJNMMI physics · 2023Review
- Evaluations of the performances of PET and MRI in a simultaneous PET/MRI instrument for pre-clinical imaging.EJNMMI physics · 2022Article
- Silicon photomultiplier signal readout and multiplexing techniques for positron emission tomography: a review.Biomedical engineering letters · 2022Review
- A Brief History of Nuclear Medicine Physics, Instrumentation, and Data Sciences in Korea.Nuclear medicine and molecular imaging · 2021Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn this study, a small animal PET insert (SimPET-X, Brightonix Imaging Inc.) for simultaneous PET/MR imaging studies is presented. This insert covers an 11-cm-long axial field-of-view (FOV) and enables imaging of mouse total-bodies and rat heads. PROCEDURES: SimPET-X comprises 16 detector modules to yield a ring diameter of 63 mm and an axial FOV of 110 mm. The detector module supports four detector blocks, each comprising two 4 × 4 SiPM arrays coupled with a 20 × 9 array of LSO crystals (1.2 × 1.2 × 10 mm
resultsThe radial spatial resolutions at the center based on 3D OSEM without and with the warm background were 0.73 mm and 0.99 mm, respectively. The absolute peak sensitivity of the system was 10.44% with an energy window of 100-900 keV and 8.27% with an energy window of 250-750 keV. The peak NECR and scatter fraction for the mouse phantom were 348 kcps at 26.2 MBq and 22.1% with an energy window of 250-750 keV, respectively. The standard deviation of pixel value in the uniform region of an NEMA IQ phantom was 4.57%. The spillover ratios for air- and water-filled chambers were 9.0% and 11.0%, respectively. In the hot-rod phantom image reconstructed using 3D OSEM-PSF, all small rods were resolved owing to the high spatial resolution of the SimPET-X system. There was no notable interference between SimPET-X and M7 MRI. SimPET-X provided high-quality mouse images with superior spatial resolution, sensitivity, and counting rate performance.
conclusionSimPET-X yielded a remarkably improved sensitivity and NECR compared with SimPET
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.