Evidence map›Paper›PMID 33768432›Full record

ArticleObesity surgery2021

Analysis of the Functional Aspects of Sperm and Testicular Oxidative Stress in Individuals Undergoing Metabolic Surgery.

Roberta Maria Fariello, Renata Cristina de Carvalho, Deborah M Spaine, Rhayza R Andretta, Elesiário M Caetano, Gustavo P D Sá, Agnaldo P Cedenho, Renato Fraietta

Abstract read
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In one paragraph

Article in Obesity surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Effect of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy on Male Sexual Function: A Systematic Review and Meta-Analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
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  4. Review
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  7. Oxidative Stress Responses in Obese Individuals Undergoing Bariatric Surgery: Impact on Carcinogenesis.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Roberta Maria FarielloDivision of Urology, Department of Surgery, Human Reproduction Section, Sao Paulo Federal University, R Napoleão de Barros, 715, 2° floor, Vila Clementino, São Paulo, SP, 04024-002, Brazil. ro.fariello@yahoo.com.br.ORCID 0000-0002-0551-5834
Renata Cristina de CarvalhoDivision of Urology, Department of Surgery, Human Reproduction Section, Sao Paulo Federal University, R Napoleão de Barros, 715, 2° floor, Vila Clementino, São Paulo, SP, 04024-002, Brazil.
Deborah M SpaineDivision of Urology, Department of Surgery, Human Reproduction Section, Sao Paulo Federal University, R Napoleão de Barros, 715, 2° floor, Vila Clementino, São Paulo, SP, 04024-002, Brazil.
Rhayza R AndrettaDivision of Urology, Department of Surgery, Human Reproduction Section, Sao Paulo Federal University, R Napoleão de Barros, 715, 2° floor, Vila Clementino, São Paulo, SP, 04024-002, Brazil.
Elesiário M CaetanoDivision of Surgical Gastroenterology, Department of Surgery, Sao Paulo Federal University, R Napoleão de Barros, 715 - 2° floor - Vila Clementino, São Paulo, SP, 04024-002, Brazil.
Gustavo P D SáGastro's Clinic, R Borges Lagoa, 1070, São Paulo, SP, 04038-002, Brazil.
Agnaldo P CedenhoDivision of Urology, Department of Surgery, Human Reproduction Section, Sao Paulo Federal University, R Napoleão de Barros, 715, 2° floor, Vila Clementino, São Paulo, SP, 04024-002, Brazil.
Renato FraiettaDivision of Urology, Department of Surgery, Human Reproduction Section, Sao Paulo Federal University, R Napoleão de Barros, 715, 2° floor, Vila Clementino, São Paulo, SP, 04024-002, Brazil.
Universidade Federal de São Paulo · BRCenter for Human Reproduction · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMetabolic surgery is a recommended treatment for obese patients that results in BMI reduction; however, the observed impact of this therapy on male fertility is inconsistent. This research aimed to study the effects of BMI changes after metabolic surgery on seminal analysis, sex hormonal profile, sperm functional integrity, and the seminal plasma lipid peroxidation levels. MATERIALS AND

methodsA prospective study was performed in 15 patients for whom metabolic surgery was recommended. The patients were evaluated by the techniques proposed in this study before and after the surgical procedure for 12 months. In each analysis, the male sex hormonal profile, semen analysis, sperm functional integrity, and seminal lipid peroxidation levels were assessed.

resultsThe surgery resulted in BMI reduction and improvement in seminal characteristics and male sex hormone profile. The semen analysis showed increases in volume, sperm progressive motility, and in sperm morphology and a decrease in immotile sperms. Sperm mitochondrial activity and sperm DNA integrity were improved, and the levels of seminal lipid peroxidation were decreased. The hormonal profile showed lower levels of estradiol and highest levels of luteinizing hormone (LH), sex hormone-binding globulin (SHBG), and testosterone.

conclusionBMI changes resulting from this treatment and its metabolic consequences can be associated with changes in the male fertile potential, leading to an improvement in the seminal quality, male sex hormone profile, sperm functional aspects, and levels of seminal lipid peroxidation, thus decreasing the testicular oxidative stress.

Indexed as

Bariatric SurgeryInfertility, MaleObesity, MorbidHumansMaleOxidative StressProspective StudiesSemen AnalysisSpermatozoaSperm CountBariatric surgeryObesityOxidative stressSemen analysisSperm DNA fragmentation

Identifiers

PMID33768432
OpenAlexW3136726832

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.