ArticleActa diabetologica2021
Association of higher HbA1c within the normal range with adverse pregnancy outcomes: a cross-sectional study.
Article in Acta diabetologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 25 citations in OpenAlex.
- miR-326 serves as a diagnostic biomarker in gestational diabetes mellitus and its regulatory effect on trophoblast cell viability.Irish journal of medical science · 2025Article
- Causal Associations Between Pre-Pregnancy Diabetes Mellitus and Pre-Eclampsia Risk: Insights from a Mendelian Randomization Study.Healthcare (Basel, Switzerland) · 2025Article
- Predictive Value of Second Trimester HbA1c for Adverse Perinatal Outcomes: A Comparative Study in Diabetic and Non-Diabetic Pregnancies.International journal of women's health · 2025Article
- The Impact of Gestational Diabetes Mellitus on the Development of Preeclampsia in Twin Pregnancies: A Retrospective Cohort Study Conducted at a Tertiary Hospital.International journal of women's health · 2025Article
- Trimester-specific reference intervals for hemoglobin A1c in non-diabetic pregnancy in a Chinese population.BMC pregnancy and childbirth · 2023Article
- Correlation between sKL and Nrf2 plasma levels and calcium oxalate urolithiasis.International urology and nephrology · 2023Article
- Continuous Glucose Monitoring System Profile of Women Stratified Using Different Levels of Glycated Hemoglobin (HbA1c) in Early Pregnancy: A Cross-sectional Study.Advances in therapy · 2023Article
- Association between fasting plasma glucose variability and maternal and infant outcomes in patients with hyperglycemia during pregnancy: a retrospective cohort study.Annals of translational medicine · 2023Article
- The association between maternal HbA1c and adverse outcomes in gestational diabetes.Frontiers in endocrinology · 2023Article
- Continuous Glucose Monitoring System Profile of Women with Gestational Diabetes Mellitus Missed Using Isolated Fasting Plasma Glucose-Based Strategies Alternative to WHO 2013 Criteria: A Cross-Sectional Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2022Article
- HbA1c at term delivery and adverse pregnancy outcome.BMC pregnancy and childbirth · 2022Article
- Gestational Diabetes Mellitus and Preeclampsia: Correlation and Influencing Factors.Frontiers in cardiovascular medicine · 2022Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe aim of this study was to investigate the association between a relatively high HbA1c level within the normal range and the risk of adverse pregnancy outcomes.
methodsThis retrospective cohort study was conducted between March 2018 and March 2019 at Women's Hospital, School of Medicine, Zhejiang University. Multiple logistic regression models after adjusting for plausible confounders were implemented to assess the relationships between the level of HbA1c and adverse pregnancy outcomes.
resultsA total of 8585 women were included in our study. The rates of preterm birth, macrosomia and preeclampsia were 4.4% (380/8585), 5.3% (457/8585) and 1.7% (149/8585), respectively. After adjusting for potential confounding variables, an HbA1c range of 5.5-5.9% (37-41 mmol/mol) remained significantly associated with an increased risk of preterm delivery (a-OR 2.27; 95% CI, 1.50-3.43), macrosomia (a-OR 1.97; 95% CI, 1.32-2.94) and preeclampsia (a-OR 3.70; 95% CI, 2.07-6.60). GDM-negative pregnant women with an HbA1c level in the range of 5.5-5.9% (37-41 mmol/mol) had an increased risk of preterm delivery (a-OR 2.84; 95% CI, 1.71-4.71) and preeclampsia (a-OR 3.82; 95% CI, 1.81-8.04). However, GDM-positive pregnant women had an increased risk of macrosomia (a-OR 2.12; 95% CI, 1.13-3.97) and preeclampsia (a-OR 2.62; 95% CI, 1.01-6.81).
conclusionA higher HbA1c level within the normal range is an independent risk factor for preterm delivery and preeclampsia, especially among GDM-negative women. Therefore, relevant medical staff should enhance the awareness of risk and prevention to strengthen pregnancy monitoring.
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