Evidence map›Paper›PMID 33768273›Full record

ArticleImmunogenetics2021

Plasma cell immunoglobulin heavy chain repertoire dynamics before and after tetanus booster vaccination.

Kyle J Wolf, Adebowale A Adeyemo, Kim C Williamson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunogenetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Kyle J WolfDepartment of Molecular Microbiology and Immunology, Saint Louis University, Saint Louis, MO, 63104, USA.
Adebowale A AdeyemoCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20814, USA.
Kim C WilliamsonDepartment of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA. kim.williamson@usuhs.edu.ORCID 0000-0003-2749-4082
Cox & Company (United States) · USNational Institutes of Health · USUniformed Services University of the Health Sciences · US

Funding

A Systems Biology Approach to Malaria ImmunityU01AI110852 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI WILLIAMSON, KIM C · 2016 to 2019
$2.8M
Plasmodium falciparum gametocytogenesisR01AI069314 · NIAID · LOYOLA UNIVERSITY OF CHICAGO · PI WILLIAMSON, KIM C · 2007 to 2017
$2.8M
A Systems Biology Approach to Malaria ImmunityR01AI110852 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI WILLIAMSON, KIM C · 2015 to 2015
$778k
NIAID NIH HHS R01 AI069314NIAID NIH HHS R01 AI110852NIAID NIH HHS U01 AI110852
6 · The paper itself

Abstract

Antibody sequence repertoire analysis of plasma cells (PC) isolated before and 1 week after a vaccine provides time-specific snapshots of the antibody response. Comparison of the immunoglobulin (Ig) sequences pre- and post-vaccination allows analysis of maturation over time and identification of antigen specific Ig. Here we compare the Ig heavy chain (Ig-H) repertoire of circulating PCs isolated from 10

Indexed as

Complementarity Determining RegionsHealthy VolunteersHumansImmunoglobulin Heavy ChainsLeukocytes, MononuclearPlasma CellsTetanus ToxoidVaccinationComplementarity Determining RegionsImmunoglobulin Heavy ChainsTetanus ToxoidAntibody maturationAntibody repertoireIg sequence analysisTetanus toxoidVaccine

Identifiers

PMID33768273
PMCPMC9254697
OpenAlexW3136159740

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.