Evidence map›Paper›PMID 33768216›Full record

ArticleJournal of experimental neurology2021

Commentary on Vulnerability and Resilience to Activity-Based Anorexia and the Role of Dopamine.

Jeff A Beeler, Nesha S Burghardt

Open access · hybridAbstract read
In one paragraph

Article in Journal of experimental neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jeff A BeelerDepartment of Psychology, Queens College, CUNY, Flushing, NY, 11367 USA.
Nesha S BurghardtDepartment of Psychology, Hunter College, CUNY, New York, NY, 10065 USA.

Funding

BP-ENDURE at Hunter and NYUR25NS080686 · NINDS · HUNTER COLLEGE · PI Nesha Star Burghardt, GLENN E SCHAFE · 2012 to 2026
$9.2M
Dissecting contributions of different D2R populations to activity and appetiteR15DA046058 · NIDA · QUEENS COLLEGE · PI BEELER, JEFF A. · 2018 to 2018
$462k
Circuit-Level Regulation of Fear and Safety Learning in Chronically Stressed MiceR21MH114182 · NIMH · HUNTER COLLEGE · PI BURGHARDT, NESHA STAR, LIKHTIK, EKATERINA · 2018 to 2019
$429k
NIDA NIH HHS R15 DA046058NIMH NIH HHS R21 MH114182NINDS NIH HHS R25 NS080686
6 · The paper itself

Abstract

Activity-based anorexia (ABA) is a commonly used rodent model of anorexia nervosa that is based on observations made in rats decades ago. In recently published work, we describe using this paradigm to model vulnerability and resilience to anorexia nervosa in mice, where vulnerability is characterized by hyperactivity and life-threatening weight loss and resilience is characterized by adaptation and weight stabilization. Using genetically modified hyperdopaminergic mice, we also demonstrate that increased dopamine augments vulnerability to ABA. Here, we briefly review our findings and discuss how obtaining vulnerable and resilient phenotypes enhances utility of the ABA model for understanding the neurobiological basis of anorexia nervosa. We comment on our dopamine findings and close by discussing implications for clinical treatment.

Indexed as

Activity-based anorexiaAnimal modelAnorexia nervosaC57BL/6Caloric restrictionDopamineHyperactivityMiceResilienceVulnerability

Identifiers

PMID33768216
PMCPMC7990270
OpenAlexW3133456458

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.