Evidence map›Paper›PMID 33768201›Full record

ArticleJournal of translational autoimmunity2021

Sanjaykumar V Boddul, Ravi Kumar Sharma, Anatoly Dubnovitsky, Bruno Raposo, Christina Gerstner, Yunbing Shen, Vaishnavi Srinivasan Iyer, Zsolt Kasza, William W Kwok, Aaron R Winkler and 4 more

Abstract read
In one paragraph

Article in Journal of translational autoimmunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. A rapid CRISPR competitive assay forComputational and structural biotechnology journal · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sanjaykumar V BoddulDivision of Rheumatology, Department of Medicine Solna, Center for Molecular Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
Ravi Kumar SharmaDivision of Rheumatology, Department of Medicine Solna, Center for Molecular Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
Anatoly DubnovitskyDivision of Rheumatology, Department of Medicine Solna, Center for Molecular Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
Bruno RaposoDivision of Rheumatology, Department of Medicine Solna, Center for Molecular Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
Christina GerstnerDivision of Rheumatology, Department of Medicine Solna, Center for Molecular Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
Yunbing ShenDivision of Rheumatology, Department of Medicine Solna, Center for Molecular Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
Vaishnavi Srinivasan IyerDivision of Rheumatology, Department of Medicine Solna, Center for Molecular Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
Zsolt KaszaDivision of Rheumatology, Department of Medicine Solna, Center for Molecular Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
William W KwokTranslational Research Program, BRI at Virginia Mason, Seattle, WA, USA.
Aaron R WinklerDepartment of Inflammation and Immunology, Pfizer Inc., Cambridge, MA, USA.
Lars KlareskogDivision of Rheumatology, Department of Medicine Solna, Center for Molecular Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
Vivianne MalmströmDivision of Rheumatology, Department of Medicine Solna, Center for Molecular Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
Maria BettiniDivision of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, USA.
Fredrik WermelingDivision of Rheumatology, Department of Medicine Solna, Center for Molecular Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.

Funding

TCR PARAMETERS OF TREG FUNCTION IN AUTOIMMUNITYR01AI125301 · NIAID · UNIVERSITY OF UTAH · PI BETTINI, MARIA · 2017 to 2021
$1.9M
NIAID NIH HHS R01 AI125301
6 · The paper itself

Abstract

Recent advances in single-cell sequencing technologies enable the generation of large-scale data sets of paired TCR sequences from patients with autoimmune disease. Methods to validate and characterize patient-derived TCR data are needed, as well as relevant model systems that can support the development of antigen-specific tolerance inducing drugs. We have generated a pipeline to allow streamlined generation of 'artificial' T cells in a robust and reasonably high throughput manner for

Indexed as

APC, antigen presenting cellsBM, bone marrowCa2+, calciumCell linesGAD, glutamic acid decarboxylaseGFP, green fluorescent proteinGWAS, Genome-wide association studiesHA, Influenza hemagglutininhCD4, human CD4HLAHLA, Human leukocyte antigenHSCs, hematopoietic stem cellshTCR, human TCRHumanized animal modelsMHC, major histocompatibility complexNFAT, Nuclear factor of activated T-cellsRAG, Recombination-activating genesRA, Rheumatoid arthritisT1D, Type-1 diabetesTCRTCRa, TCR alphaTCRb, TCR betaTCR, T cell receptorTMR, HLA tetramerTolerance

Identifiers

PMID33768201
PMCPMC7980064

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.