Evidence map›Paper›PMID 33768027›Full record

ArticleIndian dermatology online journal

The Diagnostic Value of Congenital and Nevoid Cutaneous Lesions Associated with Autism Spectrum Disorders in Indian Children- A Case-Control Study.

Sirisha Varala, Renu George, Lydia Mathew, Paul Russell, Beena Koshy, Samuel P Oommen, Maya Thomas, Karthik Muthusamy, Sangeetha Yoganathan, L Jeyaseelan and 1 more

Open access · diamondAbstract read
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Article in Indian dermatology online journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Sirisha VaralaDepartment of Dermatology, Venereology and Leprosy, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
Renu GeorgeDepartment of Dermatology, Venereology and Leprosy, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
Lydia MathewDepartment of Dermatology, Venereology and Leprosy, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
Paul RussellDepartment of Child and Adolescent Psychiatry, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
Beena KoshyDepartment of Developmental Pediatrics, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
Samuel P OommenDepartment of Developmental Pediatrics, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
Maya ThomasDepartment of Pediatric Neurology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
Karthik MuthusamyDepartment of Pediatric Neurology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
Sangeetha YoganathanDepartment of Pediatric Neurology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
L JeyaseelanDepartment of Biostatistics, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
Jayaprakash MuliyilDivision of Gastrointestinal Sciences, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
Christian Medical College & Hospital · INChristian Medical College · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsCutaneous lesions are the defining features of several neurocutaneous syndromes like neurofibromatosis1(NF1), tuberous sclerosis complex (TSC), and Sturge Weber syndrome to name a few. With this background, we explored the possibility of identifying congenital and nevoid cutaneous markers that may help in the early recognition of autism spectrum disorders (ASD) in Indian children. The objective of this study was to measure the strength of association between congenital and nevoid cutaneous lesions and ASD among Indian children.

methodsA case-control study was conducted from January 2018 to June 2018. 132 children (18 months-16 years of age) with ASD and equal number of age and sex-matched children without autism were studied. Diagnosis of ASD was based on DSM-5 criteria. All the children were examined for cutaneous lesions with special attention to nevoid and congenital conditions. The strength of association was measured using the diagnostic odds ratio (OR).

resultsThe prevalence of congenital and nevoid lesions were higher in ASD group (OR = 3.12,

conclusionThe presence of hyperpigmented pigmentary mosaicism and CALMs warrant closer surveillance by the caregivers and physicians for evolving features of autism. Larger multicentric studies are required to validate these findings.

Indexed as

Autismcongenital and nevoid lesionsDiagnostic value

Identifiers

PMID33768027
PMCPMC7982006
OpenAlexW3124203532

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.