ArticleMolecular and clinical oncology2021
Methylation and molecular profiles of ependymoma: Influence of patient age and tumor anatomic location.
Article in Molecular and clinical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- SNUH methylation classifier for CNS tumors.Clinical epigenetics · 2025Article
- Article
- ATRT-SHH comprises three molecular subgroups with characteristic clinical and histopathological features and prognostic significance.Acta neuropathologica · 2022Article
- An Overview of Intracranial Ependymomas in Adults.Cancers · 2021Review
- Molecular profiling of pediatric and adolescent ependymomas: identification of genetic variants using a next-generation sequencing panel.Journal of neuro-oncology · 2021Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ependymomas are tumors of the central nervous system that can occur in patients of all ages. Guidelines from the World Health Organization (WHO) for the grading of ependymomas consider patient age, tumor resection range, tumor location and histopathological grade. However, recent studies have suggested that a greater focus on both tumor location and patient age in terms of transcriptomic, genetic, and epigenetic analyses may provide a more accurate assessment of clinical prognosis than the grading system proposed by WHO guidelines. The current study identified the differences and similarities in ependymoma characteristics using three different molecular analyses and methylation arrays. Primary intracranial ependymoma tissues were obtained from 13 Korean patients (9 adults and 4 children), after which whole-exome sequencing (WES), ion-proton comprehensive cancer panel (CCP) analysis, RNA sequencing, and Infinium HumanMethylation450 BeadChip array analysis was performed. Somatic mutations, copy number variations, and fusion genes were identified. It was observed that the methylation status and differentially expressed genes were significantly different according to tumor location and patient age. Several novel gene fusions and somatic mutations were identified, including a
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