ArticleThe World Allergy Organization journal2021
Incidence and timing of offspring asthma, wheeze, allergic rhinitis, atopic dermatitis, and food allergy and association with maternal history of asthma and allergic rhinitis.
Article in The World Allergy Organization journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Risk Factors for the Development of Food Allergy in Infants and Children: A Systematic Review and Meta-Analysis.JAMA pediatrics · 2026Pooled it
- Maternal asthma during pregnancy and risks of allergy and asthma in progeny: A systematic review and meta-analysis.BJOG : an international journal of obstetrics and gynaecology · 2025Pooled it
- Prevalence of eczema between cesarean-born and vaginal-born infants within 1 year of age: a systematic review and meta-analysis.European journal of pediatrics · 2022Pooled it
- Ultra-Processed Food Consumption and Childhood Allergic Diseases: Increased Risk of Asthma Onset in the SENDO Project.Allergy · 2026Article
- Altered expression of Toll-like receptor 9 in the lung tissue of adult mice generated by in vitro embryo culture and embryo transfer.Histochemistry and cell biology · 2026Article
- Associations Between the Maternal Diet Index and Childhood Asthma: The NorthPop and Healthy Start Cohorts.Clinical and translational allergy · 2025Article
- Maternal mental health disorders associate with their child's asthma: A register-based study.Brain, behavior, & immunity - health · 2025Article
- Maternal asthma imprints fetal lung ILC2s via glucocorticoid signaling leading to worsened allergic airway inflammation in murine adult offspring.Nature communications · 2025Article
- A support vector machine-based tool for rapid pediatric asthma exacerbation risk assessment: development and nursing application.Frontiers in pediatrics · 2025Article
- Recommendations for Clinicians to Combat Environmental Disparities in Pediatric Asthma: A Review.Chest · 2024Review
- Wildfire Seasons, Prenatal PMACS ES&T air · 2024Article
- Prenatal Factors in the Development of Allergic Diseases.International journal of molecular sciences · 2024Review
- Evaluation of Childhood Allergy Risk Among Pregnant Women in a Tertiary Care Hospital in Thailand.Cureus · 2024Article
- Nonelective cesarean section is associated with the prevalence of asthma among Mexican children who attended childcare centers.Asia Pacific allergy · 2024Article
- Preclinical models of maternal asthma and progeny outcomes: a scoping review.European respiratory review : an official journal of the European Respiratory Society · 2024Article
- Prenatal exposure to poly- and perfluoroalkyl substances and the incidence of asthma in early childhood.Environmental research · 2023Article
- Birth order, sibship size, and risk of atopic dermatitis, food allergy, and atopy: A systematic review and meta-analysis.Clinical and translational allergy · 2023Review
- Immunomodulatory effects of modified Liu-Wei-Di-Huang-Wan Traditional Chinese medicine on allergic asthmatic mice.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023Article
- Food allergy among Mexican infants and preschoolers: prevalence and associated factors.World journal of pediatrics : WJP · 2023Article
- Investigations on incidence and relevant factors of allergies in 5725 urban pregnant women: a cohort study in China.BMC public health · 2023Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundStudying the developmental precursors of allergy may help explain the mechanisms (or etiology) of allergic disease. We studied childhood respiratory and allergic diseases in a pre-birth cohort from the United States.
objectiveWe assessed the associations between maternal history of asthma and the development of respiratory and allergic diseases in offspring. We also assessed associations with maternal history of allergic rhinitis.
methodsMaternal history of asthma and allergic rhinitis was self-reported during early pregnancy. Offspring respiratory and allergy information was obtained from electronic medical records. Adjusted Cox proportional hazard models assessed the associations between maternal history of asthma and development of respiratory and allergic diseases in the offspring up to 8 years. A similar approach was used for maternal history of allergic rhinitis.
resultsChildren born to women with a history of asthma had a 77% greater risk of developing asthma, a 45% greater risk of atopic dermatitis/eczema, and a 65% greater risk of wheeze (all p < 0.01), but no significantly increased risk of allergic rhinitis or food allergies, compared to children born to women with no history of asthma. Maternal history of allergic rhinitis was not associated with any child allergy outcome, and maternal history of both asthma and allergic rhinitis was associated with child atopic dermatitis/eczema only.
conclusionsMaternal history of asthma was significantly associated with offspring respiratory and allergic diagnoses. The association between maternal history of asthma and offspring asthma and atopic dermatitis is a novel finding. Our findings may guide physicians who counsel families with a history of maternal asthma and allergic rhinitis about their child's risk of developing respiratory and allergic diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.