Evidence map›Paper›PMID 33767697›Full record

ArticleFrontiers in immunology2021

Hydrogen Attenuates Endotoxin-Induced Lung Injury by Activating Thioredoxin 1 and Decreasing Tissue Factor Expression.

Qian Li, Liang Hu, Juan Li, Pan Yu, Fan Hu, Bing Wan, Miaomiao Xu, Huixian Cheng, Wanyou Yu, Liping Jiang and 5 more

Open access · goldAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases.Oxidative medicine and cellular longevity · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Qian LiDepartment of Anesthesiology, Jiangning Hospital Affiliated to Nanjing Medical University, Nanjing, China.
Liang HuJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, China.
Juan LiDepartment of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.
Pan YuDepartment of Burn and Plastic Surgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.
Fan HuJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, China.
Bing WanDepartment of Anesthesiology, Jiangning Hospital Affiliated to Nanjing Medical University, Nanjing, China.
Miaomiao XuDepartment of Anesthesiology, Jinling College Affiliated to Nanjing Medical University, Nanjing, China.
Huixian ChengDepartment of Anesthesiology, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, China.
Wanyou YuDepartment of Anesthesiology, Jiangning Hospital Affiliated to Nanjing Medical University, Nanjing, China.
Liping JiangDepartment of Anesthesiology, Jiangning Hospital Affiliated to Nanjing Medical University, Nanjing, China.
Yadan ShiDepartment of Anesthesiology, Jiangning Hospital Affiliated to Nanjing Medical University, Nanjing, China.
Jincan LiJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, China.
Manlin DuanDepartment of Anesthesiology, Jinling College Affiliated to Nanjing Medical University, Nanjing, China.
Yun LongDepartment of Anesthesiology, Jiangning Hospital Affiliated to Nanjing Medical University, Nanjing, China.
Wen-Tao LiuDepartment of Anesthesiology, Jiangning Hospital Affiliated to Nanjing Medical University, Nanjing, China.
Nanjing Medical University · CNNanjing Jiangning Hospital · CNNanjing General Hospital of Nanjing Military Command · CNNanjing University · CNSouthern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endotoxin-induced lung injury is one of the major causes of death induced by endotoxemia, however, few effective therapeutic options exist. Hydrogen inhalation has recently been shown to be an effective treatment for inflammatory lung injury, but the underlying mechanism is unknown. In the current study we aim to investigate how hydrogen attenuates endotoxin-induced lung injury and provide reference values for the clinical application of hydrogen. LPS was used to establish an endotoxin-induced lung injury mouse model. The survival rate and pulmonary pathologic changes were evaluated. THP-1 and HUVECC cells were cultured

Indexed as

Acute Lung InjuryAnimalsAnti-Inflammatory AgentsCoculture TechniquesDisease Models, AnimalDown-RegulationHumansHuman Umbilical Vein Endothelial CellsHydrogenInterleukin-6LipopolysaccharidesLungMacrophagesMaleMatrix Metalloproteinase 9MiceAnti-Inflammatory AgentsHydrogenInterleukin-6interleukin-6, mouseLipopolysaccharidesMatrix Metalloproteinase 9MMP9 protein, humanMmp9 protein, mouseThioredoxinsThromboplastinTxn1 protein, mouseTXN protein, humanhydrogenlungMMP-9sepsisTFTrx1

Identifiers

PMID33767697
PMCPMC7985449
OpenAlexW3134092105

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.