Evidence map›Paper›PMID 33767696›Full record

ArticleFrontiers in immunology2021

Effect of Anti-TNF Therapy on Mucosal Apoptosis Genes Expression in Crohn's Disease.

Liliana Lykowska-Szuber, Michal Walczak, Marzena Skrzypczak-Zielinska, Joanna Suszynska-Zajczyk, Kamila Stawczyk-Eder, Katarzyna Waszak, Piotr Eder, Anna Wozniak, Iwona Krela-Kazmierczak, Ryszard Slomski and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Liliana Lykowska-SzuberDepartment of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland.
Michal WalczakInstitute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.
Marzena Skrzypczak-ZielinskaInstitute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.
Joanna Suszynska-ZajczykDepartment of Biochemistry and Biotechnology, Poznan University of Life Sciences, Poznan, Poland.
Kamila Stawczyk-EderDepartment of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland.
Katarzyna WaszakDepartment of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland.
Piotr EderDepartment of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland.
Anna WozniakThe NanoBioMedical Centre, Adam Mickiewicz University, Poznan, Poland.
Iwona Krela-KazmierczakDepartment of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland.
Ryszard SlomskiInstitute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.
Agnieszka DobrowolskaDepartment of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland.
Poznan University of Medical Sciences · PLInstitute of Human Genetics · PLAdam Mickiewicz University in Poznań · PLPolish Academy of Sciences · PLUniversity of Life Sciences in Poznań · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Crohn's disease (CD) is a chronic immune-mediated disorder for which there is not a fully effective treatment. Moreover, biological therapy with anti-tumor necrosis factor-α (anti-TNF-α) monoclonal antibodies leads to an effective response in only 60-70% of patients. Our previous data suggested that specific

Indexed as

AdultApoptosisApoptosis Regulatory ProteinsCrohn DiseaseDisease ManagementDisease SusceptibilityDuration of TherapyFemaleGene Expression RegulationHumansImmunomodulationIntestinal MucosaMaleMiddle AgedMolecular Targeted TherapyT-LymphocytesApoptosis Regulatory ProteinsTumor Necrosis Factor Inhibitorsanti-TNF therapyapoptosisCrohn's diseasegenes expressionimmunomodulation

Identifiers

PMID33767696
PMCPMC7985326
OpenAlexW3135613518

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.