ArticleNature2021
Neuronal enhancers are hotspots for DNA single-strand break repair.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 148 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
148citing papers in PubMed, 2 pooled it
13.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
148 citing papers in PubMed, 2 syntheses or guidelines pooled it, 229 citations in OpenAlex.
- Molecular Mechanisms Underlying Pluripotency and Self-Renewal of Embryonic Stem Cells.International journal of molecular sciences · 2023Pooled it
- Establishing gene regulatory networks from Parkinson's disease risk loci.Brain : a journal of neurology · 2022Pooled it
- Somatic mutations and single-nucleus transcriptomics reveal uniquely human properties of neuronal aging.bioRxiv : the preprint server for biology · 2026Article
- Elevated dNTP Pool Levels Impair Homologous Recombination and Enhance Glioblastoma Sensitivity to Irradiation and Temozolomide.International journal of molecular sciences · 2026Article
- Article
- Decoding DNA metabolism and its clinical relevance through the lens of high-throughput sequencing assays.Medical review (2021) · 2026Review
- Lead Exposure Triggers DNA Damage in TK6 Cells Via Alteration of DNA Repair Gene Expression and Hypermethylation of Ku80 Promoter Region.Biological trace element research · 2026Article
- Disruption of DNA Repair as an Emerging Epigenetic Mechanism Underlying Autism Spectrum Disorder.Current psychiatry reports · 2026Review
- PARP1 inhibition in naïve mouse embryonic stem cells induces viral mimicry.Nucleic acids research · 2026Article
- Article
- DNA Mechanical Strain Steers Transcription Factor Recognition.Research square · 2026Article
- Double strand breaks drive toxicity in a Huntington's disease mouse model with or without somatic expansion.Nature communications · 2026Article
- When R-Loops Go Awry: Genome Instability and Neurological Diseases.The European journal of neuroscience · 2026Review
- Cellular senescence in migraine - a hypothesis-driven narrative review.The journal of headache and pain · 2026Review
- CRISPR tiling deletion screens reveal functional enhancers and allelic compensation effects (ACE) on SIN3A transcription.Nature communications · 2026Article
- Hypomorphic Protein Expression of DNA Polymerase Beta in PolβBiomolecules · 2026Article
- Parkinson's disease linked LRRK2 G2019S drives oxidative nuclear DNA damage and PARP1 hyperactive signaling.bioRxiv : the preprint server for biology · 2026Article
- The expanding roles of homologous recombination proteins in genome stability.The EMBO journal · 2026Review
- A transposase-derived gene required for human brain development.Science advances · 2026Article
- Targeting DNA Damage and Repair Pathways in Cerebral Ischemic Stroke: From Bench to Bedside.Translational stroke research · 2026Review
88 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
Authors and funding
25 authors at 9 institutions in 4 countries.
Wei Wu *Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-5164-2765
Sarah E Kargbo-Hill *National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-8499-7455
William J Nathan *Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-2752-7630
Jacob PaianoLaboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.
Elsa CallenLaboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.
Dongpeng WangLaboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-8272-1228
Kenta ShinodaLaboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.
Niek van WietmarschenLaboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.
Jennifer M Colón-MercadoNational Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.
Dali ZongLaboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.
Raffaella De PaceEunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-8179-6869
Han-Yu ShihNational Eye Institute, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-7525-5433
Steve CoonEunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-5233-0277
Maia ParsadanianNational Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.
Raphael PavaniLaboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.
Hana HanzlikovaDepartment of Genome Dynamics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.ORCID http://orcid.org/0000-0001-7235-7269
Solji ParkLymphocyte Nuclear Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases and National Cancer Institute, NIH, Bethesda, MD, USA.
Seol Kyoung JungLymphocyte Nuclear Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases and National Cancer Institute, NIH, Bethesda, MD, USA.
Peter J McHughDepartment of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.ORCID http://orcid.org/0000-0002-8679-4627
Andres CanelaThe Hakubi Center for Advanced Research and Radiation Biology Center, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
Chongyi ChenLaboratory of Biochemistry and Molecular Biology, National Cancer Institute, NIH, Bethesda, MD, USA.
Rafael CasellasLymphocyte Nuclear Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases and National Cancer Institute, NIH, Bethesda, MD, USA.
Keith W CaldecottDepartment of Genome Dynamics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic. k.w.caldecott@sussex.ac.uk.ORCID http://orcid.org/0000-0003-4255-9016
Michael E WardNational Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA. wardme@nih.gov.ORCID http://orcid.org/0000-0002-5296-8051
André NussenzweigLaboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA. andre_nussenzweig@nih.gov.ORCID http://orcid.org/0000-0002-8952-7268
National Human Genome Research Institute · USNational Institute of Neurological Disorders and Stroke · USNational Institutes of Health · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USJohn Radcliffe Hospital · GBUniversity of Sussex · GBKyoto University · JPNational Cancer Institute · USNational Eye Institute · US
Funding
RAG and AID biologyZIAAR041148 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI O'SHEA, JOHN · 2009 to 2025
$44.8MDNA RepairZIABC010283 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NUSSENZWEIG, ANDRE A. · 2009 to 2025
$27.0MRelationship between DNA damage detection and signalingZIABC010959 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NUSSENZWEIG, ANDRE A. · 2009 to 2025
$27.0MMechanisms of inherited neurodegenerative diseasesZIANS003155 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI WARD, MICHAEL · 2016 to 2025
$24.7MMolecular Genomics Sequencing Core FacilityZICHD008958 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI MAHADEVAN, VIVEK · 2016 to 2025
$19.0MGenomic regulation of immune response in neurodegeneration in miceZIAEY000569 · NEI · NATIONAL EYE INSTITUTE · PI SHIH, HAN-YU · 2020 to 2025
$10.0MThe dynamics of chromatin topology in human cellsZIABC011884 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CHEN, CHONGYI · 2019 to 2025
$9.2MDNA REPAIRZ01BC010283 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NUSSENZWEIG, ANDRE A. · 1998 to 2008
$2.9MIntramural NIH HHS Z01 BC010283Medical Research Council MR/P010121/1
Abstract
Defects in DNA repair frequently lead to neurodevelopmental and neurodegenerative diseases, underscoring the particular importance of DNA repair in long-lived post-mitotic neurons
Indexed as
DNA Breaks, Single-StrandedDNA Repair5-MethylcytosineCell LineDNADNA ReplicationEnhancer Elements, GeneticHumansMaleMethylationNeuronsPoly(ADP-ribose) PolymerasesSequence Analysis, DNA5-MethylcytosineDNAPoly(ADP-ribose) Polymerases
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.