Evidence map›Paper›PMID 33767396›Full record

ArticleNature biotechnology2021

Ultra-fast proteomics with Scanning SWATH.

Christoph B Messner, Vadim Demichev, Nic Bloomfield, Jason S L Yu, Matthew White, Marco Kreidl, Anna-Sophia Egger, Anja Freiwald, Gordana Ivosev, Fras Wasim and 9 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 151 papers.

0numbers the graph read from it
0cells of the map it votes in
151citing papers in PubMed
25.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

151 citing papers in PubMed, 315 citations in OpenAlex.

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  15. Single-Injection Multi-Omics Analysis by Direct Infusion Mass Spectrometry.Angewandte Chemie (International ed. in English) · 2026
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  20. Article

91 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 4 countries.

Christoph B Messner *Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London, UK.
Vadim Demichev *Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-2424-9412
Nic BloomfieldSCIEX, Concord, Ontario, Canada.
Jason S L YuMolecular Biology of Metabolism Laboratory, The Francis Crick Institute, London, UK.
Matthew WhiteMolecular Biology of Metabolism Laboratory, The Francis Crick Institute, London, UK.
Marco KreidlMolecular Biology of Metabolism Laboratory, The Francis Crick Institute, London, UK.
Anna-Sophia EggerMolecular Biology of Metabolism Laboratory, The Francis Crick Institute, London, UK.
Anja FreiwaldDepartment of Biochemistry, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Gordana IvosevSCIEX, Concord, Ontario, Canada.
Fras WasimSCIEX, Concord, Ontario, Canada.
Aleksej ZelezniakMolecular Biology of Metabolism Laboratory, The Francis Crick Institute, London, UK.
Linda JürgensDepartment of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Norbert SuttorpDepartment of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Leif Erik SanderDepartment of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-0476-9947
Florian KurthDepartment of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-3807-473X
Kathryn S LilleyDepartment of Biochemistry, Cambridge Centre for Proteomics, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-0594-6543
Michael MüllederCore Facility - High Throughput Mass Spectrometry, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Stephen TateSCIEX, Concord, Ontario, Canada.
Markus RalserMolecular Biology of Metabolism Laboratory, The Francis Crick Institute, London, UK. markus.ralser@crick.ac.uk.ORCID http://orcid.org/0000-0001-9535-7413
The Francis Crick Institute · GBHumboldt-Universität zu Berlin · DESpinal Cord Injury BC · CAUniversity of Cambridge · GBUniversität Hamburg · DE

Funding

Medical Research Council MC_PC_17179Medical Research Council MC_PC_20060Medical Research Council MR/V028448/1Wellcome Trust 200829/Z/16/ZWellcome Trust FC001134
6 · The paper itself

Abstract

Accurate quantification of the proteome remains challenging for large sample series and longitudinal experiments. We report a data-independent acquisition method, Scanning SWATH, that accelerates mass spectrometric (MS) duty cycles, yielding quantitative proteomes in combination with short gradients and high-flow (800 µl min

Indexed as

Tandem Mass SpectrometryArabidopsisBiomarkersCell LineCOVID-19HumansPeptidesProteomeProteomicsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSeverity of Illness IndexBiomarkersPeptidesProteomeSaccharomyces cerevisiae Proteins

Identifiers

PMID33767396
PMCPMC7611254
OpenAlexW3138817412

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.