ArticleMolecular psychiatry2021
Reciprocal control of obesity and anxiety-depressive disorder via a GABA and serotonin neural circuit.
Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it, 118 citations in OpenAlex.
- Prevalence of children's mental health disorders and implications in pharmacotherapy: a systematic review and meta-analysis.Postgraduate medicine · 2025Pooled it
- Effects of Bifidobacterium breve 207-1 on regulating lifestyle behaviors and mental wellness in healthy adults based on the microbiome-gut-brain axis: a randomized, double-blind, placebo-controlled trial.European journal of nutrition · 2024Trial
- CRH neurons in the dorsal bed nucleus of the stria terminalis (dBNST) mediate contextual fear generalization.Neurobiology of stress · 2026Article
- Evaluation of Grazing Behavior and Its Associations with Obesity, Emotion Regulation Difficulties, and Problematic Smartphone Use in Adolescents with Essential Hypertension.Children (Basel, Switzerland) · 2026Article
- Corticotropin-releasing hormone neurons in the bed nucleus of the stria terminalis control wakefulness in physiological and stressful conditions in mice.Molecular psychiatry · 2026Article
- Unveiling the enigma of anxiety disorders and depression: from pathogenesis to treatment.Science China. Life sciences · 2026Review
- Cognition at the core of metabolic syndrome: linking metabolic load to behavioural impairment in a longitudinal high-fat diet rat model.Brain, behavior, & immunity - health · 2026Article
- Maternal Vitamin D Deficiency During Pregnancy Alters Hepatic Metabolism in Adult Female Offspring Without Overt Metabolic Dysfunction.Metabolites · 2026Article
- Neural mechanisms linking Western diet consumption and cognitive impairment: a role for the vagus nerve.Clinical science (London, England : 1979) · 2026Review
- Gender-Specific Depression-Anxiety Symptom Networks and the Impact of Weight Status: Insights From a Large-Scale Study.PsyCh journal · 2026Article
- Multitarget Neuropharmacological Actions of Drimycarpus racemosus Hook. f. GC-MS-Guided In Vivo and In Silico Evidence of Anxiolytic and Antidepressant Potential.TheScientificWorldJournal · 2026Article
- Associations between psychological distress and thyroid cancer, and the mediating role of lifestyle and metabolism: a cohort study from the UK Biobank.Frontiers in oncology · 2026Article
- Paternal immune activation-induced alteration of 28S rRNA-derived small RNAs in sperm reprograms offspring phenotypes.PNAS nexus · 2026Article
- Factors associated with anxiety, depression, and cognitive impairment in individuals with hypertension: a cross-sectional study based on a Chinese population.Frontiers in cardiovascular medicine · 2026Article
- Intestinal-related substances in obesity regulation: A comprehensive review.World journal of gastrointestinal pharmacology and therapeutics · 2025Review
- Similarities and differences of regional brain activity between first-episode drug-naïve anxious and nonanxious MDD patients.BMC psychiatry · 2025Article
- Article
- MentalAId: an improved DenseNet model to assist scalable psychosis assessment.BMC psychiatry · 2025Article
- A Causal Inference Study of Circulating Metabolites Mediating the Effect of Obesity-Related Indicators on the Incidence of Anxiety Disorders.Brain and behavior · 2025Article
- Identification of biomarkers related to metabolically healthy or unhealthy obesity in children and adolescents with depressive disorders: a cross-sectional study.Scientific reports · 2025Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
Abstract
The high comorbidity between obesity and mental disorders, such as depression and anxiety, often exacerbates metabolic and neurological symptoms significantly. However, neural mechanisms that underlie reciprocal control of feeding and mental states are largely elusive. Here we report that melanocortin 4 receptor (MC4R) neurons located in the dorsal bed nucleus of the stria terminus (dBNST) engage in the regulation of mentally associated weight gain by receiving GABAergic projections from hypothalamic AgRP neurons onto α5-containing GABA
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.