ArticleScientific reports2021
3D virtual reconstruction and quantitative assessment of the human intervertebral disc's annulus fibrosus: a DTI tractography study.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Biomaterials for intervertebral disc regeneration: Niche reprogramming, precision therapeutics, and structural reconstruction.Bioactive materials · 2027Review
- Stepwise micro-CT analysis of sample processing effects on the 3D morphology of human intervertebral discs.Osteoarthritis and cartilage open · 2026Article
- Evolutionary Specializations of the Human Vertebral Body and Intervertebral Disc in Relation to Bipedalism.Life (Basel, Switzerland) · 2026Article
- Qualitative and Quantitative MR Imaging of the Cartilaginous Endplate: A Review.Journal of magnetic resonance imaging : JMRI · 2025Review
- Exploring the correlation between magnetic resonance diffusion tensor imaging (DTI) parameters and aquaporin expression and biochemical composition content in degenerative intervertebral disc nucleus pulposus tissue: a clinical experimental study.BMC musculoskeletal disorders · 2025Article
- Review
- Engineering extracellular matrix-based hydrogels for intervertebral disc regeneration.Frontiers in bioengineering and biotechnology · 2025Review
- Article
- Three-dimensional fiber patterning in the annulus fibrosus can be derived from vertebral endplate topography.JOR spine · 2024Article
- Article
- Future of low back pain: unravelling IVD components and MSCs' potential.Cell regeneration (London, England) · 2024Review
- Stimuli-Responsive Delivery Systems for Intervertebral Disc Degeneration.International journal of nanomedicine · 2024Review
- Nucleus high intensity in the T2-weighted MRI is a potential predictor of annulus tear in cervical injured patients: a case comparative study.BMC musculoskeletal disorders · 2023Article
- Discogenic Low Back Pain: Anatomy, Pathophysiology and Treatments of Intervertebral Disc Degeneration.International journal of molecular sciences · 2022Review
- Effects of Different Parameter Settings for 3D Data Smoothing and Mesh Simplification on Near Real-Time 3D Reconstruction of High Resolution Bioceramic Bone Void Filling Medical Images.Sensors (Basel, Switzerland) · 2021Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intervertebral disc's (IVD) annulus fibrosus (AF) retains the hydrostatic pressure of the nucleus pulposus (NP), controls the range of motion, and maintains the integrity of the motion segment. The microstructure of the AF is not yet fully understood and quantitative characterization is lacking, leaving a caveat in modern medicine's ability to prevent and treat disc failure (e.g., disc herniation). In this study, we show a reconstruction of the 3D microstructure of the fibers that constitute the AF via MRI diffusion tensor imaging (DTI) followed by fiber tracking. A quantitative analysis presents an anisotropic structure with significant architectural differences among the annuli along the width of the fibrous belt. These findings indicate that the outer annuli's construction reinforces the IVD while providing a sufficient degree of motion. Our findings also suggest an increased role of the outer annuli in IVD nourishment.
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