ArticleCommunications biology2021
Targeted memory reactivation in REM but not SWS selectively reduces arousal responses.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Preferential consolidation of emotional reactivity during sleep: A systematic review and meta-analysis.Frontiers in behavioral neuroscience · 2022Pooled it
- REM sleep reduction leads to fear overgeneralization via negatively modulating prefrontal theta oscillations.BMC medicine · 2025Trial
- Emotional Processing in a Nap Paradigm: The Role of Sleep Stages in Memory and Reactivity.Psychophysiology · 2026Article
- The cathartic dream: Using a large language model to study a new type of functional dream in healthy and clinical populations.Journal of sleep research · 2025Article
- Investigating dreams by strategically presenting sounds during REM sleep to reactivate waking experiences.Neuropsychologia · 2025Article
- Impaired emotional memory dissipation in insomnia disorder.Psychological medicine · 2025Article
- Reactivation fails to offer the improvement sleep does.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Targeted memory reactivation during REM sleep may selectively enhance the late positive potential amplitude in previously encountered negative images: preliminary findings.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Both slow wave and rapid eye movement sleep contribute to emotional memory consolidation.Communications biology · 2025Article
- Isolated Rem Sleep Behavior Disorder: A Model to Assess the Overnight Habituation of Emotional Reactivity.Clocks & sleep · 2025Article
- Disarming emotional memories using targeted memory reactivation during rapid eye movement sleep.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Memory, Sleep, Dreams, and Consciousness: A Perspective Based on the Memory Theory of Consciousness.Nature and science of sleep · 2025Article
- Aversive memories can be weakened during human sleep via the reactivation of positive interfering memories.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Reactivating cue approached positive personality traits during sleep promotes positive self-referential processing.iScience · 2024Article
- Article
- An update on recent advances in targeted memory reactivation during sleep.NPJ science of learning · 2024Review
- Evidence of an active role of dreaming in emotional memory processing shows that we dream to forget.Scientific reports · 2024Article
- Overnight neuronal plasticity and adaptation to emotional distress.Nature reviews. Neuroscience · 2024Review
- Auditory stimulation during REM sleep modulates REM electrophysiology and cognitive performance.Communications biology · 2024Article
- Rule Abstraction Is Facilitated by Auditory Cuing in REM Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
Abstract
A growing body of evidence suggests that sleep can help to decouple the memory of emotional experiences from their associated affective charge. This process is thought to rely on the spontaneous reactivation of emotional memories during sleep, though it is still unclear which sleep stage is optimal for such reactivation. We examined this question by explicitly manipulating memory reactivation in both rapid-eye movement sleep (REM) and slow-wave sleep (SWS) using targeted memory reactivation (TMR) and testing the impact of this manipulation on habituation of subjective arousal responses across a night. Our results show that TMR during REM, but not SWS significantly decreased subjective arousal, and this effect is driven by the more negative stimuli. These results support one aspect of the sleep to forget, sleep to remember (SFSR) hypothesis which proposes that emotional memory reactivation during REM sleep underlies sleep-dependent habituation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.