ArticleScientific reports2021
Characterization of laser speckle flowgraphy pulse waveform parameters for the evaluation of the optic nerve head and retinal circulation.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Changes in ocular blood flow and haemodynamic waveform parameters following trabeculectomy.BMJ open ophthalmology · 2026Article
- Evidence That Cardiac Pulse Strains Retinal Vessels in and near the Optic Disc During Ocular Ductions.Bioengineering (Basel, Switzerland) · 2026Article
- Machine learning assessment of retinal blood flow links metabolic dysfunction and accelerated microvascular aging.Scientific reports · 2026Article
- Development of a laser speckle contrast imaging analysis pipeline reveals a triphasic retinal blood flow waveform.Biomedical optics express · 2026Article
- Evaluation of ocular blood flow in the assessment of symptomatic carotid stenosis.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Retinal Oxygen Kinetics and Hemodynamics in Choroidal Melanoma After Iodine-125 Plaque Radiotherapy Using a Novel Structural-Functional Imaging Analysis System.Cancer medicine · 2025Article
- Risk Score Predicting Primary Open-Angle Glaucoma Patients With Vascular Predisposition.Translational vision science & technology · 2025Article
- Alterations on Microcirculation of Optic Nerve Head Before and After OSA Surgery.Nature and science of sleep · 2025Article
- Comparisons of choroidal blood flow velocity between initial-onset acute uveitis associated with Vogt-Koyanagi-Harada disease and acute central serous chorioretinopathy.Eye (London, England) · 2024Article
- Advances in retinal imaging biomarkers for the diagnosis of cerebrovascular disease.Frontiers in neurology · 2024Review
- A retinal imaging system for combined measurement of optic nerve head vascular pulsation and stimulated vasodilation in humans.Scientific reports · 2023Article
- Retinal arterial-venous pulse delay: a new specific marker for a carotid-cavernous fistula.Frontiers in ophthalmology · 2023Article
- Sex differences in the association between systemic oxidative stress status and optic nerve head blood flow in normal-tension glaucoma.PloS one · 2023Article
- Characteristics of laterality in the optic nerve head microcirculation obtained by laser speckle flowgraphy in healthy subjects.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Article
- Longitudinal Study of Optic Disk Perfusion and Retinal Structure in Leber's Hereditary Optic Neuropathy.Investigative ophthalmology & visual science · 2022Article
- Dynamic Alterations in Blood Flow in Glaucoma Measured with Laser Speckle Contrast Imaging.Ophthalmology. GlaucomaObservational
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Authors and funding
11 authors.
Funding
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Abstract
To characterize laser speckle flowgraphy (LSFG) pulse waveform parameters for ocular circulation evaluation, a multicenter, prospective, cross-sectional study was conducted in 111 eyes of 86 healthy Japanese individuals. Optic nerve head (ONH) tissue-area, vessel-area mean blur rate (MT and MV, respectively), and MT and MV pulse waveform parameters were obtained using LSFG and ONH structural parameters using planimetry. Multivariate linear mixed-effects modeled regression analysis identified factors contributing to MT- or MV-waveforms using age, gender, smoking history, body mass index, systolic and diastolic blood pressure, heart rate, intraocular pressure, axial length, disc, rim, and β-peripapillary atrophy areas, MT or MV, central retinal artery, and vein equivalents (CRAE and CRVE) as explanatory variables. MT- and MV-waveforms significantly correlated with one or more systemic factors, consistent with previous studies. Following confounding factor adjustment, MT-Skew significantly negatively correlated with β-PPA area (P = 0.026); MT- and MV-flow acceleration index positively correlated with CRAE, MT, and MV (P = 0.041-< 0.001), compatible with these parameters' observed correlations to systemic factors. Significantly negative correlations of the blowout score and acceleration time index to CRAE partly conflicted with their correlations to systemic factors, and other waveform parameters showed little correlation to ocular factors. Thus, Skew and flow acceleration index assisted the in vivo ocular circulation characterization.
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