ArticleScientific reports2021
Exposure to low doses of pesticides induces an immune response and the production of nitric oxide in honeybees.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 44 citations in OpenAlex.
- Disruption of Antioxidant Defense Systems in Honey Bees and Wild Bees Under Environmental Xenobiotic Pressure.Antioxidants (Basel, Switzerland) · 2026Review
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- Synergistic Effects of Amitraz and Dinotefuran on Honey Bee Health: Impacts on Survival, Gene Expression, and Hypopharyngeal Gland Morphology.International journal of molecular sciences · 2025Article
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- Exposure of insects to current use pesticide residues in soil and vegetation along spatial and temporal distribution in agricultural sites.Scientific reports · 2025Article
- Changes in the life history traits in Aedes aegypti selected for resistance to permethrin and thymol, a spatial repellent.PloS one · 2025Article
- Route of exposure to veterinary products in bees: Unraveling pasture's impact on avermectin exposure and tolerance in stingless bees.PNAS nexus · 2024Article
- Midgut Cell Damage and Oxidative Stress inAntioxidants (Basel, Switzerland) · 2023Article
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- Exposure of chlorothalonil and acetamiprid reduce the survival and cause multiple internal disturbances inFrontiers in physiology · 2023Article
- Effect of amide protoporphyrin derivatives on immune response in Apis mellifera.Scientific reports · 2022Article
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- Midgut and Head Transcriptomic Analysis of Silkworms Reveals the Physiological Effects of Artificial Diets.Insects · 2022Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Honeybees are essential pollinators of many agricultural crops and wild plants. However, the number of managed bee colonies has declined in some regions of the world over the last few decades, probably caused by a combination of factors including parasites, pathogens and pesticides. Exposure to these diverse biotic and abiotic stressors is likely to trigger immune responses and stress pathways that affect the health of individual honeybees and hence their contribution to colony survival. We therefore investigated the effects of an orally administered bacterial pathogen (Pseudomonas entomophila) and low-dose xenobiotic pesticides on honeybee survival and intestinal immune responses. We observed stressor-dependent effects on the mean lifespan, along with the induction of genes encoding the antimicrobial peptide abaecin and the detoxification factor cytochrome P450 monooxygenase CYP9E2. The pesticides also triggered the immediate induction of a nitric oxide synthase gene followed by the delayed upregulation of catalase, which was not observed in response to the pathogen. Honeybees therefore appear to produce nitric oxide as a specific defense response when exposed to xenobiotic stimuli. The immunity-related and stress-response genes we tested may provide useful stressor-dependent markers for ecotoxicological assessment in honeybee colonies.
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