ArticleScientific reports2021
An intensity matched comparison of laser- and contact heat evoked potentials.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- The efficacy and mechanisms of low-intensity transcranial ultrasound stimulation on pain: a systematic review of human and animal studies.The journal of headache and pain · 2025Pooled it
- Dysregulated Pain-Autonomic Responses in Patients With Nonspecific Chronic Low Back Pain.Pain research & management · 2026Observational
- Test-retest reliability of intra-epidermal electrically evoked potentials in comparison with other modalities and across stimulation intensities.Scientific reports · 2025Article
- Assessing signs of central sensitization: A critical review of physiological measures in experimentally induced secondary hyperalgesia.European journal of pain (London, England) · 2025Review
- Understanding inter-individual variability of experimental pain habituation and conditioned pain modulation in healthy individuals.Scientific reports · 2024Article
- NeuroSense: A non-invasive and configurable somatosensory stimulator with OPENVIBE communication.HardwareX · 2024Article
- Low-Intensity Focused Ultrasound to the Human Dorsal Anterior Cingulate Attenuates Acute Pain Perception and Autonomic Responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Psychophysics of Pain: A Methodological Introduction.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2023Article
- Non-invasive neuromodulation of sub-regions of the human insula differentially affect pain processing and heart-rate variability.bioRxiv : the preprint server for biology · 2023Article
- Neural processes responsible for the translation of sustained nociceptive inputs into subjective pain experience.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Assessment and management of pain/nociception in patients with disorders of consciousness or locked-in syndrome: A narrative review.Frontiers in systems neuroscience · 2023Review
- The test-retest reliability of large and small fiber nerve excitability testing with threshold tracking.Clinical neurophysiology practice · 2023Article
- Experience with opioids does not modify the brain network involved in expectations of placebo analgesia.The European journal of neuroscience · 2022Article
- Improved acquisition of contact heat evoked potentials with increased heating ramp.Scientific reports · 2022Article
- Low-intensity focused ultrasound to the posterior insula reduces temporal summation of pain.Brain stimulationArticle
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies comparing laser (LEPs) and contact heat evoked potentials (CHEPs) consistently reported higher amplitudes following laser compared to contact heat stimulation. However, none of the studies matched the perceived pain intensity, questioning if the observed difference in amplitude is due to biophysical differences between the two methods or a mismatch in stimulation intensity. The aims of the current study were twofold: (1) to directly compare the brain potentials induced by intensity matched laser and contact heat stimulation and (2) investigate how capsaicin-induced secondary hyperalgesia modulates LEPs and CHEPs. Twenty-one healthy subjects were recruited and measured at four experimental sessions: (1) CHEPs + sham, (2) LEPs + sham, (3) CHEPs + capsaicin, and (4) LEPs + capsaicin. Baseline (sham) LEPs latency was significantly shorter and amplitude significantly larger compared to CHEPs, even when matched for perceived pain. Neither CHEPs nor LEPs was sensitive enough to detect secondary hyperalgesia. These differences provide evidence that a faster heating rate results in an earlier and more synchronized LEPs than CHEPs. To our knowledge, this was the first study to match perceived intensity of contact heat and laser stimulations, revealing distinct advantages associated with the acquisition of LEPs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.