ArticleScientific reports2021
Genome-wide characterization and analysis of bHLH transcription factors related to anthocyanin biosynthesis in spine grapes (Vitis davidii).
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 86 citations in OpenAlex.
- Identification and functional analysis of MeJA-responsive bHLH family genes in Taraxacum kok-saghyz.Journal of plant research · 2026Article
- Anthocyanin accumulation in fruit crops: a multi-layered regulatory network integrating molecular, epigenetic, hormonal and environmental regulation.Molecular biology reports · 2026Review
- Identification, characterization, and expression profiling of the bHLH gene family in Beta vulgaris.BMC plant biology · 2025Article
- Co-Analysis of Transcriptome and Metabolome Reveals Flavonoid Biosynthesis inFoods (Basel, Switzerland) · 2025Article
- Transcriptome analysis reveals the expression of genes involved in the formation of petal variegation in Impatiens morsei.Scientific reports · 2025Article
- Whole-genome identification and functional analysis of grape bHLH transcription factors: new insights into the regulation of monoterpene biosynthesis.Frontiers in plant science · 2025Article
- Functional characterization inFrontiers in plant science · 2025Article
- Evolutionary analysis of anthocyanin biosynthetic genes: insights into abiotic stress adaptation.Plant molecular biology · 2024Review
- Identification of bHLH transcription factors and screening of anthocyanin-related genes in Lagerstroemia indica.Genetica · 2024Article
- Genome-wide identification of bHLH transcription factors and expression analysis under drought stress inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2024Article
- Genome-Wide Analysis of the bHLH Gene Family inPlants (Basel, Switzerland) · 2023Article
- Advances in understanding cold tolerance in grapevine.Plant physiology · 2023Review
- Multilayered regulation of secondary metabolism in medicinal plants.Molecular horticulture · 2023Review
- Genome-Wide Identification of theInternational journal of molecular sciences · 2023Article
- Comprehensive Analysis of bHLH Transcription Factors inInternational journal of molecular sciences · 2023Article
- Genome-Wide Characterization and Analysis of bHLH Transcription Factors Related to Anthocyanin Biosynthesis inInternational journal of molecular sciences · 2023Article
- VabHLH137 promotes proanthocyanidin and anthocyanin biosynthesis and enhances resistance toHorticulture research · 2023Article
- Genome-wide identification of bHLH transcription factors and their response to salt stress inFrontiers in plant science · 2023Article
- Genome-Wide Identification of the Aconitase Gene Family in Tomato (International journal of molecular sciences · 2022Article
- Genome-wide identification and characterization of the bHLH gene family and analysis of their potential relevance to chlorophyll metabolism in Raphanus sativus L.BMC genomics · 2022Article
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Authors and funding
10 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
As one of the largest transcription factor family, basic helix-loop-helix (bHLH) transcription factor family plays an important role in plant metabolism, physiology and growth. Berry color is one of the important factors that determine grape quality. However, the bHLH transcription factor family's function in anthocyanin synthesis of grape berry has not been studied systematically. We identified 115 bHLH transcription factors in grape genome and phylogenetic analysis indicated that bHLH family could be classified into 25 subfamilies. First, we screened six candidate genes by bioinformatics analysis and expression analysis. We found one of the candidate genes VdbHLH037 belonged to III (f) subfamily and interacted with genes related to anthocyanin synthesis through phylogenetic analysis and interaction network prediction. Therefore, we speculated that VdbHLH037 participated in the anthocyanin synthesis process. To confirm this, we transiently expressed VdbHLH037 in grape and Arabidopsis transformation. Compared with the control, transgenic materials can accumulate more anthocyanins. These results provide a good base to study the function of the VdbHLH family in anthocyanin synthesis of grape berry.
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